Impact of total body irradiation‐ vs chemotherapy‐based myeloablative conditioning on outcomes of haploidentical hematopoietic cell transplantation for acute myelogenous leukemia

The optimal myeloablative conditioning (MAC) for patients undergoing haploidentical hematopoietic cell transplantation (haplo‐HCT) is unknown. We studied the outcomes of total body irradiation (TBI) vs chemotherapy (CT) based MAC regimens in acute myeloid leukemia (AML) patients. The study included...

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Veröffentlicht in:	American journal of hematology 2020-10, Vol.95 (10), p.1200-1208
Hauptverfasser:	Dholaria, Bhagirathbhai, Labopin, Myriam, Angelucci, Emanuele, Ciceri, Fabio, Diez‐Martin, Jose L., Bruno, Benedetto, Sica, Simona, Koc, Yener, Gülbas, Zafer, Schmid, Christoph, Blaise, Didier, Carella, Angelo Michele, Visani, Guiseppe, Savani, Bipin N., Nagler, Arnon, Mohty, Mohamad
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Chemotherapy Cyclophosphamide Graft rejection Graft-versus-host reaction Grafts Hematology Immunology Leukemia Life Sciences Multivariate analysis Myeloid leukemia Radiation Stem cell transplantation Transplantation Transplants & implants
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Zusammenfassung:	The optimal myeloablative conditioning (MAC) for patients undergoing haploidentical hematopoietic cell transplantation (haplo‐HCT) is unknown. We studied the outcomes of total body irradiation (TBI) vs chemotherapy (CT) based MAC regimens in acute myeloid leukemia (AML) patients. The study included 1008 patients who underwent first haplo‐HCT with post‐transplant cyclophosphamide, following TBI (N = 89, 9%) or CT (n = 919, 91%) based MAC. Patients in the TBI cohort were younger (median age, 38 vs 47 years, P
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.25934