Characteristics of IDH-mutant gliomas with non-canonical IDH mutation
Background Approximately 10% of IDH -mutant gliomas harbour non-canonical IDH mutations (non- p.R132H IDH1 and IDH2 mutations). Objective The aim of this study was to analyse the characteristics of non-canonical IDH -mutant gliomas. Materials and methods We retrospectively analysed the characterist...
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| Veröffentlicht in: | Journal of neuro-oncology 2021, Vol.151 (2), p.279-286 |
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| creator | Poetsch, L. Bronnimann, C. Loiseau, H. Frénel, J. S. Siegfried, A. Seizeur, R. Gauchotte, G. Cappellen, D. Carpentier, C. Figarella-Branger, D. Eimer, S. Meyronet, D. Ducray, F. |
| description | Background
Approximately 10% of
IDH
-mutant gliomas harbour non-canonical
IDH
mutations (non-
p.R132H IDH1
and
IDH2
mutations).
Objective
The aim of this study was to analyse the characteristics of non-canonical
IDH
-mutant gliomas.
Materials and methods
We retrospectively analysed the characteristics of 166 patients with non-canonical
IDH
mutant gliomas and compared them to those of 155 consecutive patients with
IDH1 p.R132H
mutant gliomas.
Results
The median age at diagnosis was 38 years in patients with non-canonical
IDH
mutant gliomas and 43 years in glioma patients with
IDH1 p.R132H
-mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical
IDH
mutations than in patients with
IDH1 p.R132H
mutations (22.2% vs 5.1%;
P
|
| doi_str_mv | 10.1007/s11060-020-03662-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_03141581v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2488038654</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-a778f9f26e284e4abf8bfc63d08c37c8e43b5e0d4bbb2f785b3cb01c4f0ce1403</originalsourceid><addsrcrecordid>eNp90U1vFCEYB3BiNHatfgEPZhIveqA-vAywx2Zt3Sab9FITbwRY6NLMDBVmav32ZZxaEw89AAn8ngfIH6H3BE4IgPxSCAEBGGgdTAiK71-gFWklw5JJ9hKtgAiJ2zX_cYTelHIDAFwy8hodMUahZW27Qmebg8nGjT7HMkZXmhSai69b3E-jGcbmuoupN6X5FcdDM6QBO1Pn6Ew3q2ZWY0zDW_QqmK74d4_rMfp-fna12eLd5beLzekOOw7rERspVVgHKjxV3HNjg7LBCbYH5Zh0ynNmWw97bq2lQarWMmeBOB7AecKBHaPPS9-D6fRtjr3Jv3UyUW9Pd3reA0Y4aRW5I9V-WuxtTj8nX0bdx-J815nBp6loygVRgq7JTD_-R2_SlIf6k6qUAqZEy6uii3I5lZJ9eHoBAT0HopdAdA1E_wlE39eiD4-tJ9v7_VPJ3wQqYAso9Wi49vnf3c-0fQCeUZTc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2488038654</pqid></control><display><type>article</type><title>Characteristics of IDH-mutant gliomas with non-canonical IDH mutation</title><source>SpringerLink Journals</source><creator>Poetsch, L. ; Bronnimann, C. ; Loiseau, H. ; Frénel, J. S. ; Siegfried, A. ; Seizeur, R. ; Gauchotte, G. ; Cappellen, D. ; Carpentier, C. ; Figarella-Branger, D. ; Eimer, S. ; Meyronet, D. ; Ducray, F.</creator><creatorcontrib>Poetsch, L. ; Bronnimann, C. ; Loiseau, H. ; Frénel, J. S. ; Siegfried, A. ; Seizeur, R. ; Gauchotte, G. ; Cappellen, D. ; Carpentier, C. ; Figarella-Branger, D. ; Eimer, S. ; Meyronet, D. ; Ducray, F. ; POLA network</creatorcontrib><description>Background
Approximately 10% of
IDH
-mutant gliomas harbour non-canonical
IDH
mutations (non-
p.R132H IDH1
and
IDH2
mutations).
Objective
The aim of this study was to analyse the characteristics of non-canonical
IDH
-mutant gliomas.
Materials and methods
We retrospectively analysed the characteristics of 166 patients with non-canonical
IDH
mutant gliomas and compared them to those of 155 consecutive patients with
IDH1 p.R132H
mutant gliomas.
Results
The median age at diagnosis was 38 years in patients with non-canonical
IDH
mutant gliomas and 43 years in glioma patients with
IDH1 p.R132H
-mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical
IDH
mutations than in patients with
IDH1 p.R132H
mutations (22.2% vs 5.1%;
P
< 0.05). Tumours were predominantly localised in the frontal lobe regardless of the type of
IDH
mutation. Compared to
IDH1 p.R132H
-mutant gliomas, tumours with non-canonical
IDH
mutations were more frequently found in the infratentorial region (5.5% vs 0%;
P
< 0.05) and were often multicentric (4.8% vs 0.9%;
P
< 0.05). Compared to
IDH1 P.R132H
-mutant gliomas, tumours with non-canonical
IDH1
mutations were more frequently astrocytomas (65.6% vs 43%,
P
< 0.05), while those with
IDH
2 mutations were more frequently oligodendrogliomas (85% vs 48.3%;
P
< 0.05). The median overall survival was similar in patients with
IDH1 p.R132H
-mutant gliomas and patients with non-canonical
IDH
-mutant gliomas.
Conclusion
Gliomas with non-canonical
IDH
mutations have distinct radiological and histological characteristics. The presence of such tumours seems to be associated with genetic predisposition to cancer development.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-020-03662-x</identifier><identifier>PMID: 33205355</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Astrocytoma ; Brain cancer ; Clinical Study ; Frontal lobe ; Glioma ; Life Sciences ; Medicine ; Medicine & Public Health ; Mutants ; Mutation ; Neurology ; Oncology ; Tumors</subject><ispartof>Journal of neuro-oncology, 2021, Vol.151 (2), p.279-286</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a778f9f26e284e4abf8bfc63d08c37c8e43b5e0d4bbb2f785b3cb01c4f0ce1403</citedby><cites>FETCH-LOGICAL-c409t-a778f9f26e284e4abf8bfc63d08c37c8e43b5e0d4bbb2f785b3cb01c4f0ce1403</cites><orcidid>0000-0002-2208-0545 ; 0000-0002-3604-887X ; 0000-0001-9943-4578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-020-03662-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-020-03662-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33205355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03141581$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Poetsch, L.</creatorcontrib><creatorcontrib>Bronnimann, C.</creatorcontrib><creatorcontrib>Loiseau, H.</creatorcontrib><creatorcontrib>Frénel, J. S.</creatorcontrib><creatorcontrib>Siegfried, A.</creatorcontrib><creatorcontrib>Seizeur, R.</creatorcontrib><creatorcontrib>Gauchotte, G.</creatorcontrib><creatorcontrib>Cappellen, D.</creatorcontrib><creatorcontrib>Carpentier, C.</creatorcontrib><creatorcontrib>Figarella-Branger, D.</creatorcontrib><creatorcontrib>Eimer, S.</creatorcontrib><creatorcontrib>Meyronet, D.</creatorcontrib><creatorcontrib>Ducray, F.</creatorcontrib><creatorcontrib>POLA network</creatorcontrib><title>Characteristics of IDH-mutant gliomas with non-canonical IDH mutation</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Background
Approximately 10% of
IDH
-mutant gliomas harbour non-canonical
IDH
mutations (non-
p.R132H IDH1
and
IDH2
mutations).
Objective
The aim of this study was to analyse the characteristics of non-canonical
IDH
-mutant gliomas.
Materials and methods
We retrospectively analysed the characteristics of 166 patients with non-canonical
IDH
mutant gliomas and compared them to those of 155 consecutive patients with
IDH1 p.R132H
mutant gliomas.
Results
The median age at diagnosis was 38 years in patients with non-canonical
IDH
mutant gliomas and 43 years in glioma patients with
IDH1 p.R132H
-mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical
IDH
mutations than in patients with
IDH1 p.R132H
mutations (22.2% vs 5.1%;
P
< 0.05). Tumours were predominantly localised in the frontal lobe regardless of the type of
IDH
mutation. Compared to
IDH1 p.R132H
-mutant gliomas, tumours with non-canonical
IDH
mutations were more frequently found in the infratentorial region (5.5% vs 0%;
P
< 0.05) and were often multicentric (4.8% vs 0.9%;
P
< 0.05). Compared to
IDH1 P.R132H
-mutant gliomas, tumours with non-canonical
IDH1
mutations were more frequently astrocytomas (65.6% vs 43%,
P
< 0.05), while those with
IDH
2 mutations were more frequently oligodendrogliomas (85% vs 48.3%;
P
< 0.05). The median overall survival was similar in patients with
IDH1 p.R132H
-mutant gliomas and patients with non-canonical
IDH
-mutant gliomas.
Conclusion
Gliomas with non-canonical
IDH
mutations have distinct radiological and histological characteristics. The presence of such tumours seems to be associated with genetic predisposition to cancer development.</description><subject>Astrocytoma</subject><subject>Brain cancer</subject><subject>Clinical Study</subject><subject>Frontal lobe</subject><subject>Glioma</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutants</subject><subject>Mutation</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Tumors</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp90U1vFCEYB3BiNHatfgEPZhIveqA-vAywx2Zt3Sab9FITbwRY6NLMDBVmav32ZZxaEw89AAn8ngfIH6H3BE4IgPxSCAEBGGgdTAiK71-gFWklw5JJ9hKtgAiJ2zX_cYTelHIDAFwy8hodMUahZW27Qmebg8nGjT7HMkZXmhSai69b3E-jGcbmuoupN6X5FcdDM6QBO1Pn6Ew3q2ZWY0zDW_QqmK74d4_rMfp-fna12eLd5beLzekOOw7rERspVVgHKjxV3HNjg7LBCbYH5Zh0ynNmWw97bq2lQarWMmeBOB7AecKBHaPPS9-D6fRtjr3Jv3UyUW9Pd3reA0Y4aRW5I9V-WuxtTj8nX0bdx-J815nBp6loygVRgq7JTD_-R2_SlIf6k6qUAqZEy6uii3I5lZJ9eHoBAT0HopdAdA1E_wlE39eiD4-tJ9v7_VPJ3wQqYAso9Wi49vnf3c-0fQCeUZTc</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Poetsch, L.</creator><creator>Bronnimann, C.</creator><creator>Loiseau, H.</creator><creator>Frénel, J. S.</creator><creator>Siegfried, A.</creator><creator>Seizeur, R.</creator><creator>Gauchotte, G.</creator><creator>Cappellen, D.</creator><creator>Carpentier, C.</creator><creator>Figarella-Branger, D.</creator><creator>Eimer, S.</creator><creator>Meyronet, D.</creator><creator>Ducray, F.</creator><general>Springer US</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2208-0545</orcidid><orcidid>https://orcid.org/0000-0002-3604-887X</orcidid><orcidid>https://orcid.org/0000-0001-9943-4578</orcidid></search><sort><creationdate>2021</creationdate><title>Characteristics of IDH-mutant gliomas with non-canonical IDH mutation</title><author>Poetsch, L. ; Bronnimann, C. ; Loiseau, H. ; Frénel, J. S. ; Siegfried, A. ; Seizeur, R. ; Gauchotte, G. ; Cappellen, D. ; Carpentier, C. ; Figarella-Branger, D. ; Eimer, S. ; Meyronet, D. ; Ducray, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a778f9f26e284e4abf8bfc63d08c37c8e43b5e0d4bbb2f785b3cb01c4f0ce1403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Astrocytoma</topic><topic>Brain cancer</topic><topic>Clinical Study</topic><topic>Frontal lobe</topic><topic>Glioma</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutants</topic><topic>Mutation</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poetsch, L.</creatorcontrib><creatorcontrib>Bronnimann, C.</creatorcontrib><creatorcontrib>Loiseau, H.</creatorcontrib><creatorcontrib>Frénel, J. S.</creatorcontrib><creatorcontrib>Siegfried, A.</creatorcontrib><creatorcontrib>Seizeur, R.</creatorcontrib><creatorcontrib>Gauchotte, G.</creatorcontrib><creatorcontrib>Cappellen, D.</creatorcontrib><creatorcontrib>Carpentier, C.</creatorcontrib><creatorcontrib>Figarella-Branger, D.</creatorcontrib><creatorcontrib>Eimer, S.</creatorcontrib><creatorcontrib>Meyronet, D.</creatorcontrib><creatorcontrib>Ducray, F.</creatorcontrib><creatorcontrib>POLA network</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poetsch, L.</au><au>Bronnimann, C.</au><au>Loiseau, H.</au><au>Frénel, J. S.</au><au>Siegfried, A.</au><au>Seizeur, R.</au><au>Gauchotte, G.</au><au>Cappellen, D.</au><au>Carpentier, C.</au><au>Figarella-Branger, D.</au><au>Eimer, S.</au><au>Meyronet, D.</au><au>Ducray, F.</au><aucorp>POLA network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics of IDH-mutant gliomas with non-canonical IDH mutation</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2021</date><risdate>2021</risdate><volume>151</volume><issue>2</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>Background
Approximately 10% of
IDH
-mutant gliomas harbour non-canonical
IDH
mutations (non-
p.R132H IDH1
and
IDH2
mutations).
Objective
The aim of this study was to analyse the characteristics of non-canonical
IDH
-mutant gliomas.
Materials and methods
We retrospectively analysed the characteristics of 166 patients with non-canonical
IDH
mutant gliomas and compared them to those of 155 consecutive patients with
IDH1 p.R132H
mutant gliomas.
Results
The median age at diagnosis was 38 years in patients with non-canonical
IDH
mutant gliomas and 43 years in glioma patients with
IDH1 p.R132H
-mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical
IDH
mutations than in patients with
IDH1 p.R132H
mutations (22.2% vs 5.1%;
P
< 0.05). Tumours were predominantly localised in the frontal lobe regardless of the type of
IDH
mutation. Compared to
IDH1 p.R132H
-mutant gliomas, tumours with non-canonical
IDH
mutations were more frequently found in the infratentorial region (5.5% vs 0%;
P
< 0.05) and were often multicentric (4.8% vs 0.9%;
P
< 0.05). Compared to
IDH1 P.R132H
-mutant gliomas, tumours with non-canonical
IDH1
mutations were more frequently astrocytomas (65.6% vs 43%,
P
< 0.05), while those with
IDH
2 mutations were more frequently oligodendrogliomas (85% vs 48.3%;
P
< 0.05). The median overall survival was similar in patients with
IDH1 p.R132H
-mutant gliomas and patients with non-canonical
IDH
-mutant gliomas.
Conclusion
Gliomas with non-canonical
IDH
mutations have distinct radiological and histological characteristics. The presence of such tumours seems to be associated with genetic predisposition to cancer development.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33205355</pmid><doi>10.1007/s11060-020-03662-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2208-0545</orcidid><orcidid>https://orcid.org/0000-0002-3604-887X</orcidid><orcidid>https://orcid.org/0000-0001-9943-4578</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 2021, Vol.151 (2), p.279-286 |
| issn | 0167-594X 1573-7373 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03141581v1 |
| source | SpringerLink Journals |
| subjects | Astrocytoma Brain cancer Clinical Study Frontal lobe Glioma Life Sciences Medicine Medicine & Public Health Mutants Mutation Neurology Oncology Tumors |
| title | Characteristics of IDH-mutant gliomas with non-canonical IDH mutation |
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