Characteristics of IDH-mutant gliomas with non-canonical IDH mutation

Characteristics of IDH-mutant gliomas with non-canonical IDH mutation

Background Approximately 10% of IDH -mutant gliomas harbour non-canonical IDH mutations (non- p.R132H IDH1  and IDH2 mutations). Objective The aim of this study was to analyse the characteristics of non-canonical IDH -mutant gliomas. Materials and methods We retrospectively analysed the characterist...

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Veröffentlicht in:Journal of neuro-oncology 2021, Vol.151 (2), p.279-286
Hauptverfasser: Poetsch, L., Bronnimann, C., Loiseau, H., Frénel, J. S., Siegfried, A., Seizeur, R., Gauchotte, G., Cappellen, D., Carpentier, C., Figarella-Branger, D., Eimer, S., Meyronet, D., Ducray, F.
Format: Artikel
Sprache:eng
Schlagworte:
Astrocytoma
Brain cancer
Clinical Study
Frontal lobe
Glioma
Life Sciences
Medicine
Medicine & Public Health
Mutants
Mutation
Neurology
Oncology
Tumors
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Zusammenfassung:Background Approximately 10% of IDH -mutant gliomas harbour non-canonical IDH mutations (non- p.R132H IDH1  and IDH2 mutations). Objective The aim of this study was to analyse the characteristics of non-canonical IDH -mutant gliomas. Materials and methods We retrospectively analysed the characteristics of 166 patients with non-canonical IDH mutant gliomas and compared them to those of 155 consecutive patients with IDH1 p.R132H mutant gliomas. Results The median age at diagnosis was 38 years in patients with non-canonical IDH mutant gliomas and 43 years in glioma patients with IDH1 p.R132H -mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical IDH mutations than in patients with IDH1 p.R132H mutations (22.2% vs 5.1%; P  
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-020-03662-x