Preparative access to transformation products (TPs) of furosemide: a versatile application of anodic oxidation

Furosemide, a pharmaceutical prescribed for the treatment of edema and hypertension, is a known contaminant of water. In this study, chemoselective anodic oxidation was implemented to assist in the identification and the preparation of furosemide transformation products (TPs), i.e., compounds derivi...

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Veröffentlicht in:	Tetrahedron 2011-12, Vol.67 (49), p.9518-9521
Hauptverfasser:	Laurencé, Céline, Rivard, Michael, Lachaise, Isabelle, Bensemhoun, Julia, Martens, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Anodic oxidation Anodizing Chemical Sciences Chemistry Contaminants Edema Exact sciences and technology Furosemide Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Hypertension Mathematical analysis Metabolites Noncondensed benzenic compounds Organic chemistry Preparations and properties Tetrahedrons Transformation products Transformations
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Beschreibung
Zusammenfassung:	Furosemide, a pharmaceutical prescribed for the treatment of edema and hypertension, is a known contaminant of water. In this study, chemoselective anodic oxidation was implemented to assist in the identification and the preparation of furosemide transformation products (TPs), i.e., compounds deriving from furosemide and likely to appear in the environment. An aniline and a pyridinium are proposed as plausible TPs and an analytical study of the pyridinium is presented. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2011.10.006