Signal Transduction Pathways and Modulation of Gene Activity

Research over the last decade has provided us with much information about the mechanisms that integrate signal transduction pathways with specific gene expression programs. We discuss the types of mechanisms used by different pathways to modulate transcription factor activity, citing examples from d...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 1998-08, Vol.36 (8), p.535-539
Hauptverfasser:	Weitzman, Jonathan B., Yaniv, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Nucleus - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Interferons - metabolism Interleukins - metabolism Life Sciences Molecular and cellular biology Molecular genetics NF-kappa B Phosphorylation Retinoblastoma Protein - metabolism Signal Transduction Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing
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Beschreibung
Zusammenfassung:	Research over the last decade has provided us with much information about the mechanisms that integrate signal transduction pathways with specific gene expression programs. We discuss the types of mechanisms used by different pathways to modulate transcription factor activity, citing examples from diverse molecular systems. Careful regulation of these pathways is essential to maintain balanced transcriptional control. Understanding the mechanisms that control gene activity will enable us to intervene therapeutically in diseases associated with deregulated transcriptional activity.
ISSN:	1434-6621 1437-4331
DOI:	10.1515/CCLM.1998.091