Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior

Highlights • Depression induced by chronic corticosterone treatment generates neuroinflammation. • Enriched environment reduces depression-linked neuroinflammation. • Enriched environment promotes anti-inflammatory microglia and brain macrophage phenotype. • Adiponectin exerts anti-inflammatory prop...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2015-11, Vol.50, p.275-287
Hauptverfasser:	Chabry, Joëlle, Nicolas, Sarah, Cazareth, Julie, Murris, Emilie, Guyon, Alice, Glaichenhaus, Nicolas, Heurteaux, Catherine, Petit-Paitel, Agnès
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adiponectin - administration & dosage Adiponectin - genetics Adiponectin - metabolism Allergy and Immunology Animals Antidepressant Brain macrophages Corticosterone - administration & dosage Cytokines Cytokines - metabolism Depression Depression - chemically induced Depression - complications Depression - metabolism Encephalitis - complications Encephalitis - metabolism Enriched environment Environment Hippocampus - metabolism Hypothalamus - metabolism Injections, Intraventricular Life Sciences Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - metabolism Neuroinflammation Phenotype Psychiatry RNA, Messenger - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Depression induced by chronic corticosterone treatment generates neuroinflammation. • Enriched environment reduces depression-linked neuroinflammation. • Enriched environment promotes anti-inflammatory microglia and brain macrophage phenotype. • Adiponectin exerts anti-inflammatory properties by acting on microglia and brain macrophages. • Adiponectin intracerebroventricular injection reduces depressive-like behavior.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.07.018