The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates
•Ultra-high dose rate reduces adverse side effects in radiotherapy (FLASH effect).•Studies and implementation in practice requires accurate dose measurements.•An European joint research project was started to develop a measurement framework.•Tools for dosimetry of ultra-high pulse dose rate beams wi...
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Veröffentlicht in: | Physica medica 2020-12, Vol.80, p.134-150 |
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creator | Schüller, Andreas Heinrich, Sophie Fouillade, Charles Subiel, Anna De Marzi, Ludovic Romano, Francesco Peier, Peter Trachsel, Maria Fleta, Celeste Kranzer, Rafael Caresana, Marco Salvador, Samuel Busold, Simon Schönfeld, Andreas McEwen, Malcolm Gomez, Faustino Solc, Jaroslav Bailat, Claude Linhart, Vladimir Jakubek, Jan Pawelke, Jörg Borghesi, Marco Kapsch, Ralf-Peter Knyziak, Adrian Boso, Alberto Olsovcova, Veronika Kottler, Christian Poppinga, Daniela Ambrozova, Iva Schmitzer, Claus-Stefan Rossomme, Severine Vozenin, Marie-Catherine |
description | •Ultra-high dose rate reduces adverse side effects in radiotherapy (FLASH effect).•Studies and implementation in practice requires accurate dose measurements.•An European joint research project was started to develop a measurement framework.•Tools for dosimetry of ultra-high pulse dose rate beams will be provided.
UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates is a recently started European Joint Research Project with the aim to develop and improve dosimetry standards for FLASH radiotherapy, very high energy electron (VHEE) radiotherapy and laser-driven medical accelerators. This paper gives a short overview about the current state of developments of radiotherapy with FLASH electrons and protons, very high energy electrons as well as laser-driven particles and the related challenges in dosimetry due to the ultra-high dose rate during the short radiation pulses. We summarize the objectives and plans of the UHDpulse project and present the 16 participating partners. |
doi_str_mv | 10.1016/j.ejmp.2020.09.020 |
format | Article |
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UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates is a recently started European Joint Research Project with the aim to develop and improve dosimetry standards for FLASH radiotherapy, very high energy electron (VHEE) radiotherapy and laser-driven medical accelerators. This paper gives a short overview about the current state of developments of radiotherapy with FLASH electrons and protons, very high energy electrons as well as laser-driven particles and the related challenges in dosimetry due to the ultra-high dose rate during the short radiation pulses. We summarize the objectives and plans of the UHDpulse project and present the 16 participating partners.</description><subject>Absorbed dose</subject><subject>Dosimetry</subject><subject>European metrology project</subject><subject>FLASH beams</subject><subject>High dose rates</subject><subject>Physics</subject><subject>Traceability</subject><issn>1120-1797</issn><issn>1724-191X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhSMEoqXwBzggH-GQMHacZCNxqUphQYtAqJW4WY4z3jhK1sF2Fu2NM1f-Ib8ERyk9Ill-o9E37_BekjynkFGg5es-w36cMgYMMqizKA-Sc1oxntKafnsYZ8ogpVVdnSVPvO8BcsaK4nFylud0Qznn58mvmw7J9ezshPJAPlpzCOQrepROdeSLsz2qQG63b6d58Ej-_PxNPmFwdrD7E9HWEdke5UFhS5xsjQ0dOjmdyOzNYU8m6YJRA5IG5ejJDxM6Mg_BybQz-46slq2Nn5MB_dPkkZZx9exOL5Lbd9c3V9t09_n9h6vLXap4zkO6UYXUChjGV_Aq101VFBtZcM1LRiU0TLNGbyhAU3JslKYlKNS61Tmrm7LIL5JXq28nBzE5M0p3ElYasb3ciWUHOVAKRXmkkX25spOz32f0QYzGKxwGeUA7e8F4CVUJMcuIshVVznrvUN97UxBLX6IXS19i6UtALaLEoxd3_nMzYnt_8q-gCLxZAYyJHA064ZXBJXHjYjWiteZ__n8BZ72pDw</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Schüller, Andreas</creator><creator>Heinrich, Sophie</creator><creator>Fouillade, Charles</creator><creator>Subiel, Anna</creator><creator>De Marzi, Ludovic</creator><creator>Romano, Francesco</creator><creator>Peier, Peter</creator><creator>Trachsel, Maria</creator><creator>Fleta, Celeste</creator><creator>Kranzer, Rafael</creator><creator>Caresana, Marco</creator><creator>Salvador, Samuel</creator><creator>Busold, Simon</creator><creator>Schönfeld, Andreas</creator><creator>McEwen, Malcolm</creator><creator>Gomez, Faustino</creator><creator>Solc, Jaroslav</creator><creator>Bailat, Claude</creator><creator>Linhart, Vladimir</creator><creator>Jakubek, Jan</creator><creator>Pawelke, Jörg</creator><creator>Borghesi, Marco</creator><creator>Kapsch, Ralf-Peter</creator><creator>Knyziak, Adrian</creator><creator>Boso, Alberto</creator><creator>Olsovcova, Veronika</creator><creator>Kottler, Christian</creator><creator>Poppinga, Daniela</creator><creator>Ambrozova, Iva</creator><creator>Schmitzer, Claus-Stefan</creator><creator>Rossomme, Severine</creator><creator>Vozenin, Marie-Catherine</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-8577-2381</orcidid><orcidid>https://orcid.org/0000-0002-6147-8425</orcidid><orcidid>https://orcid.org/0000-0002-6860-7859</orcidid><orcidid>https://orcid.org/0000-0002-8754-673X</orcidid><orcidid>https://orcid.org/0000-0002-3582-4638</orcidid><orcidid>https://orcid.org/0000-0003-2692-5645</orcidid></search><sort><creationdate>20201201</creationdate><title>The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates</title><author>Schüller, Andreas ; Heinrich, Sophie ; Fouillade, Charles ; Subiel, Anna ; De Marzi, Ludovic ; Romano, Francesco ; Peier, Peter ; Trachsel, Maria ; Fleta, Celeste ; Kranzer, Rafael ; Caresana, Marco ; Salvador, Samuel ; Busold, Simon ; Schönfeld, Andreas ; McEwen, Malcolm ; Gomez, Faustino ; Solc, Jaroslav ; Bailat, Claude ; Linhart, Vladimir ; Jakubek, Jan ; Pawelke, Jörg ; Borghesi, Marco ; Kapsch, Ralf-Peter ; Knyziak, Adrian ; Boso, Alberto ; Olsovcova, Veronika ; Kottler, Christian ; Poppinga, Daniela ; Ambrozova, Iva ; Schmitzer, Claus-Stefan ; Rossomme, Severine ; Vozenin, Marie-Catherine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-8c5afc02e02e5473fb7558a54f4621a0b2f2bf8100b64ebcf160ceffdf329b653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Absorbed dose</topic><topic>Dosimetry</topic><topic>European metrology project</topic><topic>FLASH beams</topic><topic>High dose rates</topic><topic>Physics</topic><topic>Traceability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schüller, Andreas</creatorcontrib><creatorcontrib>Heinrich, Sophie</creatorcontrib><creatorcontrib>Fouillade, Charles</creatorcontrib><creatorcontrib>Subiel, Anna</creatorcontrib><creatorcontrib>De Marzi, Ludovic</creatorcontrib><creatorcontrib>Romano, Francesco</creatorcontrib><creatorcontrib>Peier, Peter</creatorcontrib><creatorcontrib>Trachsel, Maria</creatorcontrib><creatorcontrib>Fleta, Celeste</creatorcontrib><creatorcontrib>Kranzer, Rafael</creatorcontrib><creatorcontrib>Caresana, Marco</creatorcontrib><creatorcontrib>Salvador, Samuel</creatorcontrib><creatorcontrib>Busold, Simon</creatorcontrib><creatorcontrib>Schönfeld, Andreas</creatorcontrib><creatorcontrib>McEwen, Malcolm</creatorcontrib><creatorcontrib>Gomez, Faustino</creatorcontrib><creatorcontrib>Solc, Jaroslav</creatorcontrib><creatorcontrib>Bailat, Claude</creatorcontrib><creatorcontrib>Linhart, Vladimir</creatorcontrib><creatorcontrib>Jakubek, Jan</creatorcontrib><creatorcontrib>Pawelke, Jörg</creatorcontrib><creatorcontrib>Borghesi, Marco</creatorcontrib><creatorcontrib>Kapsch, Ralf-Peter</creatorcontrib><creatorcontrib>Knyziak, Adrian</creatorcontrib><creatorcontrib>Boso, Alberto</creatorcontrib><creatorcontrib>Olsovcova, Veronika</creatorcontrib><creatorcontrib>Kottler, Christian</creatorcontrib><creatorcontrib>Poppinga, Daniela</creatorcontrib><creatorcontrib>Ambrozova, Iva</creatorcontrib><creatorcontrib>Schmitzer, Claus-Stefan</creatorcontrib><creatorcontrib>Rossomme, Severine</creatorcontrib><creatorcontrib>Vozenin, Marie-Catherine</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Physica medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schüller, Andreas</au><au>Heinrich, Sophie</au><au>Fouillade, Charles</au><au>Subiel, Anna</au><au>De Marzi, Ludovic</au><au>Romano, Francesco</au><au>Peier, Peter</au><au>Trachsel, Maria</au><au>Fleta, Celeste</au><au>Kranzer, Rafael</au><au>Caresana, Marco</au><au>Salvador, Samuel</au><au>Busold, Simon</au><au>Schönfeld, Andreas</au><au>McEwen, Malcolm</au><au>Gomez, Faustino</au><au>Solc, Jaroslav</au><au>Bailat, Claude</au><au>Linhart, Vladimir</au><au>Jakubek, Jan</au><au>Pawelke, Jörg</au><au>Borghesi, Marco</au><au>Kapsch, Ralf-Peter</au><au>Knyziak, Adrian</au><au>Boso, Alberto</au><au>Olsovcova, Veronika</au><au>Kottler, Christian</au><au>Poppinga, Daniela</au><au>Ambrozova, Iva</au><au>Schmitzer, Claus-Stefan</au><au>Rossomme, Severine</au><au>Vozenin, Marie-Catherine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates</atitle><jtitle>Physica medica</jtitle><addtitle>Phys Med</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>80</volume><spage>134</spage><epage>150</epage><pages>134-150</pages><issn>1120-1797</issn><eissn>1724-191X</eissn><abstract>•Ultra-high dose rate reduces adverse side effects in radiotherapy (FLASH effect).•Studies and implementation in practice requires accurate dose measurements.•An European joint research project was started to develop a measurement framework.•Tools for dosimetry of ultra-high pulse dose rate beams will be provided.
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subjects | Absorbed dose Dosimetry European metrology project FLASH beams High dose rates Physics Traceability |
title | The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates |
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