The European Joint Research Project UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates

•Ultra-high dose rate reduces adverse side effects in radiotherapy (FLASH effect).•Studies and implementation in practice requires accurate dose measurements.•An European joint research project was started to develop a measurement framework.•Tools for dosimetry of ultra-high pulse dose rate beams wi...

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Veröffentlicht in:Physica medica 2020-12, Vol.80, p.134-150
Hauptverfasser: Schüller, Andreas, Heinrich, Sophie, Fouillade, Charles, Subiel, Anna, De Marzi, Ludovic, Romano, Francesco, Peier, Peter, Trachsel, Maria, Fleta, Celeste, Kranzer, Rafael, Caresana, Marco, Salvador, Samuel, Busold, Simon, Schönfeld, Andreas, McEwen, Malcolm, Gomez, Faustino, Solc, Jaroslav, Bailat, Claude, Linhart, Vladimir, Jakubek, Jan, Pawelke, Jörg, Borghesi, Marco, Kapsch, Ralf-Peter, Knyziak, Adrian, Boso, Alberto, Olsovcova, Veronika, Kottler, Christian, Poppinga, Daniela, Ambrozova, Iva, Schmitzer, Claus-Stefan, Rossomme, Severine, Vozenin, Marie-Catherine
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Sprache:eng
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Zusammenfassung:•Ultra-high dose rate reduces adverse side effects in radiotherapy (FLASH effect).•Studies and implementation in practice requires accurate dose measurements.•An European joint research project was started to develop a measurement framework.•Tools for dosimetry of ultra-high pulse dose rate beams will be provided. UHDpulse – Metrology for advanced radiotherapy using particle beams with ultra-high pulse dose rates is a recently started European Joint Research Project with the aim to develop and improve dosimetry standards for FLASH radiotherapy, very high energy electron (VHEE) radiotherapy and laser-driven medical accelerators. This paper gives a short overview about the current state of developments of radiotherapy with FLASH electrons and protons, very high energy electrons as well as laser-driven particles and the related challenges in dosimetry due to the ultra-high dose rate during the short radiation pulses. We summarize the objectives and plans of the UHDpulse project and present the 16 participating partners.
ISSN:1120-1797
1724-191X
DOI:10.1016/j.ejmp.2020.09.020