6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases
6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.
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| Veröffentlicht in: | Journal of antibiotics 2000/10/25, Vol.53(10), pp.1022-1027 |
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| container_end_page | 1027 |
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| container_issue | 10 |
| container_start_page | 1022 |
| container_title | Journal of antibiotics |
| container_volume | 53 |
| creator | GOLEMI, DASANTILA MAVEYRAUD, LAURENT ISHIWATA, AKIHIRO TRAMER, SAMUEL MIYASHITA, KAZUYUKI NAGASE, TSUYOSHI MASSOVA, IRINA MOUREY, LIONEL SAMAMA, JEAN-PIERRE MOBASHERY, SHAHRIAR |
| description | 6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases. |
| doi_str_mv | 10.7164/antibiotics.53.1022 |
| format | Article |
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The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.53.1022</identifier><identifier>PMID: 11132946</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>6-(Hydroxyalkyl)penicillanates ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; beta-Lactamase Inhibitors ; beta-Lactamases - chemistry ; beta-Lactamases - metabolism ; Biological and medical sciences ; Chemical Sciences ; Drug Design ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; Life Sciences ; Medical sciences ; Molecular Probes ; Penicillanic Acid - analogs & derivatives ; Penicillanic Acid - chemistry ; Penicillanic Acid - metabolism ; Penicillanic Acid - pharmacology ; Pharmacology. 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Antibiot.</addtitle><description>6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.</description><subject>6-(Hydroxyalkyl)penicillanates</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>beta-Lactamase Inhibitors</subject><subject>beta-Lactamases - chemistry</subject><subject>beta-Lactamases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chemical Sciences</subject><subject>Drug Design</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Life Sciences</subject><subject>Medical sciences</subject><subject>Molecular Probes</subject><subject>Penicillanic Acid - analogs & derivatives</subject><subject>Penicillanic Acid - chemistry</subject><subject>Penicillanic Acid - metabolism</subject><subject>Penicillanic Acid - pharmacology</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>beta-Lactamase Inhibitors</topic><topic>beta-Lactamases - chemistry</topic><topic>beta-Lactamases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chemical Sciences</topic><topic>Drug Design</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Life Sciences</topic><topic>Medical sciences</topic><topic>Molecular Probes</topic><topic>Penicillanic Acid - analogs & derivatives</topic><topic>Penicillanic Acid - chemistry</topic><topic>Penicillanic Acid - metabolism</topic><topic>Penicillanic Acid - pharmacology</topic><topic>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 2000/10/25, Vol.53(10), pp.1022-1027 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_03004369v1 |
| source | J-STAGE Free; MEDLINE |
| subjects | 6-(Hydroxyalkyl)penicillanates Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactamase Inhibitors beta-Lactamases - chemistry beta-Lactamases - metabolism Biological and medical sciences Chemical Sciences Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Life Sciences Medical sciences Molecular Probes Penicillanic Acid - analogs & derivatives Penicillanic Acid - chemistry Penicillanic Acid - metabolism Penicillanic Acid - pharmacology Pharmacology. Drug treatments Substrate Specificity |
| title | 6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases |
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