6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases

6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2000/10/25, Vol.53(10), pp.1022-1027
Hauptverfasser:	GOLEMI, DASANTILA, MAVEYRAUD, LAURENT, ISHIWATA, AKIHIRO, TRAMER, SAMUEL, MIYASHITA, KAZUYUKI, NAGASE, TSUYOSHI, MASSOVA, IRINA, MOUREY, LIONEL, SAMAMA, JEAN-PIERRE, MOBASHERY, SHAHRIAR
Format:	Artikel
Sprache:	eng
Schlagworte:	6-(Hydroxyalkyl)penicillanates Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactamase Inhibitors beta-Lactamases - chemistry beta-Lactamases - metabolism Biological and medical sciences Chemical Sciences Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Life Sciences Medical sciences Molecular Probes Penicillanic Acid - analogs & derivatives Penicillanic Acid - chemistry Penicillanic Acid - metabolism Penicillanic Acid - pharmacology Pharmacology. Drug treatments Substrate Specificity
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Beschreibung
Zusammenfassung:	6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of β-lactamases, enzymes of resistance for β-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of β-lactamases.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.1022