Worldwide emergence of colistin resistance in Klebsiella pneumoniae from healthy humans and patients in Lao PDR, Thailand, Israel, Nigeria and France owing to inactivation of the PhoP/PhoQ regulator mgrB : an epidemiological and molecular study

Highlights • The human gut can harbour clonally unrelated colistin-resistant K. pneumoniae. • Mutation in mgrB is an emerging mechanism associated with colistin resistance. • mgrB mutations account for higher resistance than mutations in pmrAB or phoPQ.

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of antimicrobial agents 2014-12, Vol.44 (6), p.500-507
Hauptverfasser:	Olaitan, Abiola Olumuyiwa, Diene, Seydina M, Kempf, Marie, Berrazeg, Meryem, Bakour, Sofiane, Gupta, Sushim Kumar, Thongmalayvong, Boupha, Akkhavong, Kongsap, Somphavong, Silaphet, Paboriboune, Phimpha, Chaisiri, Kittipong, Komalamisra, Chalit, Adelowo, Olawale Olufemi, Fagade, Obasola Ezekiel, Banjo, Omowunmi Abosede, Oke, Adeyeye James, Adler, Amos, Assous, Marc Victor, Morand, Serge, Raoult, Didier, Rolain, Jean-Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - pharmacology Antibiotic resistance Bacterial Proteins - genetics Biochemistry, Molecular Biology Colistin - pharmacology Colistin resistance Drug Resistance, Bacterial Feces - microbiology France - epidemiology Genome analysis Genome, Bacterial - genetics Humans Infectious Disease Israel - epidemiology Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Laos - epidemiology Life Sciences Male mgrB gene Molecular Sequence Data Nigeria - epidemiology Santé publique et épidémiologie Sequence Alignment Sequence Analysis, DNA Thailand - epidemiology Transposon Two-component systems
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Beschreibung
Zusammenfassung:	Highlights • The human gut can harbour clonally unrelated colistin-resistant K. pneumoniae. • Mutation in mgrB is an emerging mechanism associated with colistin resistance. • mgrB mutations account for higher resistance than mutations in pmrAB or phoPQ.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2014.07.020