A Flexible Method for Covalent Double Functionalization of Graphene Oxide
A method for the double functionalization of graphene oxide (GO) under mild alkaline conditions has been developed. Two functional groups were covalently linked to GO in two steps: the first group was attached by an epoxide ring‐opening reaction and the second, bearing an amine function, was covalen...
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Veröffentlicht in: | Angewandte Chemie International Edition 2020-01, Vol.59 (4), p.1542-1547 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A method for the double functionalization of graphene oxide (GO) under mild alkaline conditions has been developed. Two functional groups were covalently linked to GO in two steps: the first group was attached by an epoxide ring‐opening reaction and the second, bearing an amine function, was covalently conjugated to benzoquinone attached to the GO. The doubly functionalized GO was characterized by several techniques, confirming the sequential covalent modification of the GO surface with two different functional groups. This method is straightforward and the reaction conditions are mild, allowing preservation of the structure and properties of GO. This strategy could be exploited to prepare multifunctional GO conjugates with potential applications in many fields ranging from materials science to biomedicine.
Accessorizing: A versatile method for the chemoselective double functionalization of graphene oxide has been developed. The method involves epoxide ring opening by a protected aminoethanethiol, and subsequent reaction of the hydroxy groups with benzoquinone followed by Michael addition of an amine derivative. |
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ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.201913461 |