Combining Designer Cells and Click Chemistry for a One-Pot Four-Step Preparation of Enantiopure β-Hydroxytriazoles

Combining Designer Cells and Click Chemistry for a One-Pot Four-Step Preparation of Enantiopure β-Hydroxytriazoles

The multistep catalytic process using designer cells, either added as freshly prepared suspensions or as stable lyophilized powder, and click reaction can be performed in one pot. The sequence of four reactions allows the production of both enantiomers of β‐hydroxytriazoles with high enantiomeric ex...

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Veröffentlicht in:Advanced synthesis & catalysis 2010-09, Vol.352 (13), p.2111-2115
Hauptverfasser: Szymanski, Wiktor, Postema, Christiaan P., Tarabiono, Chiara, Berthiol, Florian, Campbell-Verduyn, Lachlan, de Wildeman, Stefaan, de Vries, Johannes G., Feringa, Ben L., Janssen, Dick B.
Format: Artikel
Sprache:eng
Schlagworte:
azides
biocatalysis
Chemical Sciences
click chemistry
designer cells
halohydrin dehalogenase
reaction cascade
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Beschreibung
Zusammenfassung:The multistep catalytic process using designer cells, either added as freshly prepared suspensions or as stable lyophilized powder, and click reaction can be performed in one pot. The sequence of four reactions allows the production of both enantiomers of β‐hydroxytriazoles with high enantiomeric excess.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201000502