Copper-Catalyzed Double C–H Alkylation of Aldehyde-Derived N,N‑Dialkylhydrazones with Polyhalomethanes: Flexible Access to 4‑Functionalized Pyrazoles

Copper-Catalyzed Double C–H Alkylation of Aldehyde-Derived N,N‑Dialkylhydrazones with Polyhalomethanes: Flexible Access to 4‑Functionalized Pyrazoles

Here, 4-functionalized pyrazoles have been made accessible in a single step from readily available aldehyde-derived N,N-dialkyl hydrazones and functionalized polyhalomethane derivatives. The process is believed to follow copper-catalyzed cascade C­(sp2)–H haloalkylation/C­(sp3)–H cyclization/aromati...

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Veröffentlicht in:ACS catalysis 2016-10, Vol.6 (10), p.7197-7201
Hauptverfasser: Prieto, Alexis, Bouyssi, Didier, Monteiro, Nuno
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Organic chemistry
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Zusammenfassung:Here, 4-functionalized pyrazoles have been made accessible in a single step from readily available aldehyde-derived N,N-dialkyl hydrazones and functionalized polyhalomethane derivatives. The process is believed to follow copper-catalyzed cascade C­(sp2)–H haloalkylation/C­(sp3)–H cyclization/aromatization reaction sequences.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.6b02439