CellSearch® technology applied to the detection and quantification of tumor cells in CSF of patients with lung cancer leptomeningeal metastasis

Highlights • This is a pilot study in patients with LM due to lung cancer. • It focused on detecting CSFTC according to an adapted CellSearch® technology. • Of 18 LM patients enrolled, 14 were detected CSFTCs. • CSFTC clusters were common in CSF of lung cancer patients with LM.

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Bibliographische Detailangaben
Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-11, Vol.90 (2), p.352-357
Hauptverfasser:	Tu, Qian, Wu, Xianglei, Le Rhun, Emilie, Blonski, Marie, Wittwer, Basile, Taillandier, Luc, De Carvalho Bittencourt, Marcelo, Faure, Gilbert C
Format:	Artikel
Sprache:	eng
Schlagworte:	CellSearch Cerebrospinal Fluid - cytology Cytodiagnosis - methods Hematology, Oncology and Palliative Medicine Humans Leptomeningeal metastasis Life Sciences Lung cancer Lung Neoplasms - pathology Magnetic Resonance Imaging - methods Meningeal Carcinomatosis - pathology Neoplastic Cells, Circulating - pathology Pilot Projects Pulmonary/Respiratory Tumor cell
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Beschreibung
Zusammenfassung:	Highlights • This is a pilot study in patients with LM due to lung cancer. • It focused on detecting CSFTC according to an adapted CellSearch® technology. • Of 18 LM patients enrolled, 14 were detected CSFTCs. • CSFTC clusters were common in CSF of lung cancer patients with LM.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2015.09.008