Inhibition of Cu-Amyloid-β by using Bifunctional Peptides with β-Sheet Breaker and Chelator Moieties

Breaking the mold: Inhibition of toxic amyloid‐β (Aβ) aggregates and disruption of Cu‐Aβ with subsequent redox‐silencing of Cu have been considered promising strategies against Alzheimer's disease. The design and proof of concept of simple peptides containing a Cu‐chelating/redox‐silencing unit and an Aβ‐aggregation inhibition unit (β‐sheet breaker) is described (see scheme).