Early Control of HIV-1 Infection in Long-Term Nonprogressors Followed Since Diagnosis in the ANRS SEROCO/HEMOCO Cohort

BACKGROUND:To clarify early correlates and natural history of HIV long-term nonprogressors (LTNPs) since HIV diagnosis. METHODS:Patients enrolled in the French ANRS SEROCO/HEMOCO cohort with CD4 count >500 cells/mm at HIV diagnosis. LTNP status was defined as being asymptomatic, antiretroviral free, and with CD4 cell count >500 cells/mm for >8 years after HIV diagnosis. In LTNPs, we modeled the biological markersʼ progression through a joint model. Factors associated with loss of LTNP status were identified through a Cox model. RESULTS:Sixty (9%) of 664 patients were identified as LTNPs during follow-up. At enrollment, HIV RNA was ≤2.6 log copies/mL in 24% of LTNPs and HIV DNA was ≤1.85 log copies/10 peripheral blood mononuclear cells (PBMCs) in 31% vs. 3% and 8% in others. In LTNPs, HIV RNA and HIV DNA levels increased by 0.04 log copies/mL per year and 0.07 log copies/10 PBMCs per year during the first 8 years after diagnosis. LTNP status was lost in 36 subjects; baseline HIV DNA >1.85 log copies/10 PBMCs and high HIV DNA increase were associated with an increased risk of losing LTNP status [adjusted hazard ratio2.8 (1.2-6.8) and 2.2 (1.0-4.8), respectively]. CONCLUSIONS:LTNP status is established in the first years of HIV infection, low HIV DNA level at enrollment and slow increase of HIV DNA being associated with maintained LTNP status.