Recent advances and prospects in nano drug delivery systems using lipopolyoxazolines

[Display omitted] •Summary of the broad LipoPOx macromolecular engineering.•Comparison of polyoxazoline and PEG in biomedical field: improvement of endosomal escape (PEG dilemma).•Highlights of the LipoPOx valuable assets for formulation work.•Nanoformulations for improved drug delivery via intravenous and topical routes. Facing the growing demand in nano drug delivery systems (nDDS), hybrid excipients based on natural molecules and well-defined synthetic polymers are intensively investigated. Lipopolyoxazolines (LipoPOx) composed of a polyoxazoline block (POx) and a lipid or lipid-like derivative are detailed in this review. The nature of lipids used, the route to synthesize LipoPOx and their advantages for the formulation of drugs are reported. The place of POx family in nanomedicine is discussed compared to PEG, considered as the gold standard of hydrophilic polymers. LipoPOx nanoformulations including liposomes, mixed micelles, lipid nanocapsules are provided alongside discussion of the nDDS for intravenous or topical administration.