Effects of Exogenous Methyl Oleate on the Biosynthesis of Nigericin, a Polyether Carboxylic Antibiotic, by Streptomyces hygroscopicus NRRL B-1865

The polyether carboxylic antibiotics have the ability to transport cations through biological membranes by forming lipophilic complexes. In the course of our study of the biosynthesis of nigericin, we have been able to increase the titer of polyether antibiotics over 20-fold after 7 days by adding m...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1992, Vol.56 (2), p.330-330
Hauptverfasser:	David, Lucien, Loutheiller, Henri, Bauchart, Dominique, Auboiron, Sylvie, Asselineau, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Fatty Acids - metabolism Life Sciences Nigericin - biosynthesis Oleic Acids - pharmacology Streptomyces - drug effects Streptomyces - metabolism Streptomyces hygroscopicus
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Zusammenfassung:	The polyether carboxylic antibiotics have the ability to transport cations through biological membranes by forming lipophilic complexes. In the course of our study of the biosynthesis of nigericin, we have been able to increase the titer of polyether antibiotics over 20-fold after 7 days by adding methyl oleate (1%) to the original fermentation culture of nigericin-producing Streptomyces hygroscopicus NRRL B-1865. In addition, this increased yield allowed us to isolate two new antibiotics, abierixin and epinigericin, closely related to nigericin.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.56.330