Optimization of the dwell-time for the quantitative analysis by gas chromatography-mass spectrometry

In this paper, the signal path in mass spectrometer used as a detector for gas chromatography in the selected ion monitoring mode is analyzed. The process involved an accumulation step that can be considered as a digital filter. Thus the Nyquist criterion alone is to be taken into account for the acquisition, by contrast to what appends with other detectors which require a higher number of acquired points to minimize the error during peak integration. This theoretical assumption was tested and accepted for three different levels of signal-to-noise ratio.