Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice

ABSTRACT Vitamin E supplementation constitutes a promising strategy in the prevention of neurodegenerative diseases. Here, we show that a phospholipid transfer protein (PLTP) is widely expressed in the brain where it appears to function as a transfer factor for α‐tocopherol, the main isomer of vitam...

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Veröffentlicht in:	The FASEB journal 2005-02, Vol.19 (2), p.296-297
Hauptverfasser:	Desrumaux, Catherine, Risold, Pierre-Yves, Schroeder, Henri, Deckert, Valérie, Masson, David, Athias, Anne, Laplanche, Hélène, Le Guern, Naig, Blache, Denis, Jiang, Xian-Cheng, Tall, Alan R, Desor, Didier, Lagrost, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - etiology Anxiety - physiopathology Anxiety Disorders - etiology Anxiety Disorders - physiopathology Biomarkers - metabolism Brain Chemistry Female Life Sciences Membrane Proteins - deficiency Mice Mice, Congenic Mice, Knockout neurodegenerative diseases Oxidative Stress - physiology Pharmaceutical sciences Phospholipid Transfer Proteins - deficiency PLTP-deficient mice tocopherol Vitamin E - metabolism α-tocopherol
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Zusammenfassung:	ABSTRACT Vitamin E supplementation constitutes a promising strategy in the prevention of neurodegenerative diseases. Here, we show that a phospholipid transfer protein (PLTP) is widely expressed in the brain where it appears to function as a transfer factor for α‐tocopherol, the main isomer of vitamin E. PLTP deficiency results in significant depletion of brain α‐tocopherol in both homozygous (−30.1%, P
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fj.04-2400fje