Bimodal control of stimulated food intake by the endocannabinoid system

Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB1 receptors...

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Veröffentlicht in:	Nature neuroscience 2010-03, Vol.13 (3), p.281-283
Hauptverfasser:	Puente, Nagore, Cannich, Astrid, Piazza, Pier Vincenzo, Chaouloff, Francis, Grandes, Pedro, Marsicano, Giovanni, Cota, Daniela, Bellocchio, Luigi, Lafenêtre, Pauline
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1488 631/378/1697/2601 631/92/436/2387 631/92/612/194 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Body Weight Brain Brain - drug effects Brain - physiology brief-communication Corpus Striatum - drug effects Corpus Striatum - physiology Eating - drug effects Eating - physiology Fasting Fasting - physiology Food gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neural Inhibition - drug effects Neural Inhibition - physiology Neurobiology Neurons - drug effects Neurons - physiology Neurosciences Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Receptors, GABA-A - metabolism Receptors, N-Methyl-D-Aspartate - metabolism RNA, Messenger - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Time Factors
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Zusammenfassung:	Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn.2494