Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes

The Listeria monocytogenes genome includes a large family of proteins harbouring leucine-rich repeats known as internalins (Inl). The generation of novel mutants and comparative analysis of Inl variability among Listeria and other bacterial genomes suggest that beyond the extensively-studied invasin...

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Veröffentlicht in:	Microbes and infection 2007-08, Vol.9 (10), p.1156-1166
Hauptverfasser:	Bierne, H., Sabet, C., Personnic, N., Cossart, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Imaging, Three-Dimensional Invasins Leucine-rich repeat Life Sciences Listeria monocytogenes - genetics Listeria monocytogenes - metabolism Listeria monocytogenes - pathogenicity Microbiology and Parasitology Models, Molecular Molecular Sequence Data Pathogenicity Proteins - chemistry Proteins - genetics Proteins - metabolism Surface proteins Virulence factors
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Beschreibung
Zusammenfassung:	The Listeria monocytogenes genome includes a large family of proteins harbouring leucine-rich repeats known as internalins (Inl). The generation of novel mutants and comparative analysis of Inl variability among Listeria and other bacterial genomes suggest that beyond the extensively-studied invasins, InlA and InlB, additional internalins also play important functions in the infectious process.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2007.05.003