muscle transcriptome analysis identifies positional candidate genes for a complex trait in pig

Muscle tenderness is an important complex trait for meat quality and thus for genetic improvement through animal breeding. However, the physiological or genetic control of tenderness development in muscle is still poorly understood. In this work, using transcriptome analysis, we found a relationship...

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Veröffentlicht in:Animal genetics 2008-04, Vol.39 (2), p.147-162
Hauptverfasser: Lobjois, V, Liaubet, L, SanCristobal, M, Glénisson, J, Fève, K, Rallières, J, Le Roy, P, Milan, D, Cherel, P, Hatey, F
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Sprache:eng
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Zusammenfassung:Muscle tenderness is an important complex trait for meat quality and thus for genetic improvement through animal breeding. However, the physiological or genetic control of tenderness development in muscle is still poorly understood. In this work, using transcriptome analysis, we found a relationship between gene expression variability and tenderness. Muscle (longissimus dorsi) samples from 30 F₂ pigs were characterized by Warner-Bratzler Shear Force (WBSF) on cooked meat as a measurement of muscle tenderness. Gene expression levels were measured using microarrays for 17 muscle samples selected to represent a range of WBSF values. Using a linear regression model, we determined that samples with WBSF values above 30 N could be effectively analysed for genes exhibiting a significant association of their expression level on shear force (false discovery rate
ISSN:0268-9146
1365-2052
DOI:10.1111/j.1365-2052.2007.01695.x