Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection

Single-Nucleotide Polymorphism-Defined Class I and Class III Major Histocompatibility Complex Genetic Subregions Contribute to Natural Long-term Nonprogression in HIV Infection

We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class...

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Veröffentlicht in:The Journal of infectious diseases 2012-03, Vol.205 (5), p.718-724
Hauptverfasser: Guergnon, J., Dalmasso, C., Broet, P., Meyer, L., Westrop, S. J., Imami, N., Vicenzi, E., Morsica, G., Tinelli, M., Poma, B. Zanone, Goujard, C., Potard, V., Gotch, F. M., Casoli, C., Cossarizza, A., Macciardi, F., Debré, P., Delfraissy, J. F., Galli, M., Autran, B., Costagliola, D., Poli, G., Theodorou, I., Riva, A.
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Biological and medical sciences
Chromosomes
Disease Progression
DNA-Binding Proteins - genetics
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genes
Genes, MHC Class I - genetics
Genetic loci
Genome-Wide Association Study
Histocompatibility Antigens Class I - genetics
HIV
HIV 1
HIV Infections - genetics
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Life Sciences
Major Histocompatibility Complex - genetics
Medical genetics
Medical sciences
Microbiology
Phenotypes
Polymorphism, Single Nucleotide
RNA, Long Noncoding
RNA, Untranslated
Time Factors
Transcription Factors - genetics
Transplantation immunology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:We performed a genome-wide association study comparing a cohort of 144 human immunodeficiency virus (HIV type 1-infected, untreated white long-term nonprogressors (LTNPs) with a cohort of 605 HIV-1-infected white seroconverters. Forty-seven single-nucleotide polymorphisms (SNPs), located from class I to class III major histocompatibility complex (MHC) subregions, show statistical association (false discovery rate,
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jir833