Step-Economical Synthesis of Taxol-like Tricycles through a Palladium-Catalyzed Domino Reaction

A quick and easy way to produce tricycles related to the core structure of taxanes has been achieved using a palladium‐catalyzed domino reaction (see scheme, Bz=benzoyl). These studies have been performed with function‐oriented synthesis in mind. An efficient route for the construction of new taxane scaffolds that could be decorated with various groups to achieve activities comparable or superior to taxol has been proposed.