n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet
Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were...
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| Veröffentlicht in: | British journal of nutrition 2012-05, Vol.107 (9), p.1305-1315 |
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| creator | Kasbi Chadli, Fatima Andre, Agnès Prieur, Xavier Loirand, Gervaise Meynier, Anne Krempf, Michel Nguyen, Patrick Ouguerram, Khadija |
| description | Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were studied for 20 weeks: (1) control diet (Control); (2) high-fat diet (HF); (3) high-fat diet enriched with n-3 PUFA (HFn-3) groups. The increase in body weight and fat mass in the HF compared to the Control group (P |
| doi_str_mv | 10.1017/S0007114511004387 |
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The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were studied for 20 weeks: (1) control diet (Control); (2) high-fat diet (HF); (3) high-fat diet enriched with n-3 PUFA (HFn-3) groups. The increase in body weight and fat mass in the HF compared to the Control group (P < 0·05) was not found in the HFn-3 group. Muscle TAG content was similar in the Control and HF groups, but significantly lower in the HFn-3 group (P = 0·008). Glucose tolerance was impaired in the HF compared to the Control group, but this impairment was prevented by n-3 PUFA in the HFn-3 group (P < 0·001). Plasma TAG and cholesterol were higher in the HF group compared to the Control group (P < 0·001), but lower in the HFn-3 group compared to the HF group (P < 0·001). HDL-cholesterol was lower in the HFn-3 group compared to the Control and HF groups (P < 0·0005). Hepatic secretion of TAG was lower in the HFn-3 group compared to the HF group (P < 0·005), but did not differ from the Control group. Hepatic gene expression of sterol regulatory element-binding protein-1c, diacylglycerol O-acyltransferase 2 and stearyl CoA desaturase 1 was lower in the HFn-3 group, whereas carnitine palmitoyl transferase 1 and scavenger receptor class B type 1 expression was higher (P < 0·05). In adipocytes and adipose macrophages, PPARγ and TNFα expression was higher in the HF and HFn-3 groups compared to the Control group. Endothelium relaxation was higher in the HFn-3 (P < 0·001) than in the HF and Control groups, and was correlated with glucose intolerance (P = 0·03) and cholesterol (P = 0·0003). In conclusion, n-3 PUFA prevent some metabolic disturbances induced by high-fat diet and improve endothelial function in hamsters.]]></description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114511004387</identifier><identifier>PMID: 21920060</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adipocytes - cytology ; Adipose Tissue - metabolism ; Animal Feed ; Animals ; Aorta - pathology ; Biological and medical sciences ; Body Composition ; Body Weight ; Carbohydrate Metabolism ; CD36 Antigens - metabolism ; Chemical and Process Engineering ; Cholesterol ; Cricetinae ; Diet ; Diet, High-Fat ; Dyslipidemias - metabolism ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; Engineering Sciences ; Fatty Acids, Omega-3 - metabolism ; Feeding. Feeding behavior ; Food engineering ; Fundamental and applied biological sciences. Psychology ; Glucose - metabolism ; Glucose Intolerance ; Life Sciences ; Lipid Metabolism ; Lipids - blood ; Lipoproteins, VLDL - metabolism ; Liver - metabolism ; Macrophages - cytology ; Male ; Mesocricetus ; Metabolic syndrome ; Metabolism and Metabolic Studies ; Muscles - metabolism ; Nutrition research ; Obesity ; Obesity - metabolism ; Obesity - physiopathology ; Risk factors ; Rodents ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2012-05, Vol.107 (9), p.1305-1315</ispartof><rights>Copyright © The Authors 2011</rights><rights>2015 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-488333686bc1de1f9df51e16aa8ae23cec557ceb127e104374f3ad6d3afc436e3</citedby><cites>FETCH-LOGICAL-c513t-488333686bc1de1f9df51e16aa8ae23cec557ceb127e104374f3ad6d3afc436e3</cites><orcidid>0000-0002-2306-3931 ; 0000-0002-7629-3482 ; 0000-0003-0058-6462</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114511004387/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,777,781,882,27905,27906,55609</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25821163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21920060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02644896$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasbi Chadli, Fatima</creatorcontrib><creatorcontrib>Andre, Agnès</creatorcontrib><creatorcontrib>Prieur, Xavier</creatorcontrib><creatorcontrib>Loirand, Gervaise</creatorcontrib><creatorcontrib>Meynier, Anne</creatorcontrib><creatorcontrib>Krempf, Michel</creatorcontrib><creatorcontrib>Nguyen, Patrick</creatorcontrib><creatorcontrib>Ouguerram, Khadija</creatorcontrib><title>n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description><![CDATA[Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were studied for 20 weeks: (1) control diet (Control); (2) high-fat diet (HF); (3) high-fat diet enriched with n-3 PUFA (HFn-3) groups. The increase in body weight and fat mass in the HF compared to the Control group (P < 0·05) was not found in the HFn-3 group. Muscle TAG content was similar in the Control and HF groups, but significantly lower in the HFn-3 group (P = 0·008). Glucose tolerance was impaired in the HF compared to the Control group, but this impairment was prevented by n-3 PUFA in the HFn-3 group (P < 0·001). Plasma TAG and cholesterol were higher in the HF group compared to the Control group (P < 0·001), but lower in the HFn-3 group compared to the HF group (P < 0·001). HDL-cholesterol was lower in the HFn-3 group compared to the Control and HF groups (P < 0·0005). Hepatic secretion of TAG was lower in the HFn-3 group compared to the HF group (P < 0·005), but did not differ from the Control group. Hepatic gene expression of sterol regulatory element-binding protein-1c, diacylglycerol O-acyltransferase 2 and stearyl CoA desaturase 1 was lower in the HFn-3 group, whereas carnitine palmitoyl transferase 1 and scavenger receptor class B type 1 expression was higher (P < 0·05). In adipocytes and adipose macrophages, PPARγ and TNFα expression was higher in the HF and HFn-3 groups compared to the Control group. Endothelium relaxation was higher in the HFn-3 (P < 0·001) than in the HF and Control groups, and was correlated with glucose intolerance (P = 0·03) and cholesterol (P = 0·0003). In conclusion, n-3 PUFA prevent some metabolic disturbances induced by high-fat diet and improve endothelial function in hamsters.]]></description><subject>Adipocytes - cytology</subject><subject>Adipose Tissue - metabolism</subject><subject>Animal Feed</subject><subject>Animals</subject><subject>Aorta - pathology</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body Weight</subject><subject>Carbohydrate Metabolism</subject><subject>CD36 Antigens - metabolism</subject><subject>Chemical and Process Engineering</subject><subject>Cholesterol</subject><subject>Cricetinae</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Dyslipidemias - metabolism</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Engineering Sciences</subject><subject>Fatty Acids, Omega-3 - metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Food engineering</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - metabolism</subject><subject>Glucose Intolerance</subject><subject>Life Sciences</subject><subject>Lipid Metabolism</subject><subject>Lipids - blood</subject><subject>Lipoproteins, VLDL - metabolism</subject><subject>Liver - metabolism</subject><subject>Macrophages - cytology</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>Metabolic syndrome</subject><subject>Metabolism and Metabolic Studies</subject><subject>Muscles - metabolism</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Obesity - physiopathology</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFklGL1DAQx4so3nr6AXyRgAj6UM00adp9XA7PExYUznsu02S6zdGma5Ku7OfwC5t1905RxKeQzG_mP5P_ZNlz4G-BQ_XumnNeAcgSgHMp6upBtgBZlXmhVPEwWxzC-SF-lj0J4TZda-DLx9lZAcuCc8UX2XeXC_b55nLFtp525CIbKWI7DVYzY0OcfYtOU2AYwqQtRjLsm409m1oKNu4ZOsPsuPXTjhg5M8WeBosD62ano50cs45tpsGQY9d7b9GxHscQyQfW3dVC1ttNn3cYkybFp9mjDodAz07neXZz-f7LxVW-_vTh48VqnesSRMxlXQshVK1aDYagW5quBAKFWCMVQpMuy0pTC0VFkL6nkp1Ao4zATkuhSJxnb451exyarbcj-n0zoW2uVuvm8MYLJWW9VDtI7Osjmyb9OlOIzWiDpmFAR9McGqhFJZJGXf0fLXktQaqf6Ms_0Ntp9i4N3UDyMHmrQCYKjpT2UwieuvtmgTeHRWj-WoSU8-JUeW5HMvcZd84n4NUJwKBx6Hyy2YZfXFkXSV0kTpzEcWy9NRv6rcd_yv8Ai7bJbA</recordid><startdate>20120514</startdate><enddate>20120514</enddate><creator>Kasbi Chadli, Fatima</creator><creator>Andre, Agnès</creator><creator>Prieur, Xavier</creator><creator>Loirand, Gervaise</creator><creator>Meynier, Anne</creator><creator>Krempf, Michel</creator><creator>Nguyen, Patrick</creator><creator>Ouguerram, Khadija</creator><general>Cambridge University Press</general><general>Cambridge University Press (CUP)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TS</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2306-3931</orcidid><orcidid>https://orcid.org/0000-0002-7629-3482</orcidid><orcidid>https://orcid.org/0000-0003-0058-6462</orcidid></search><sort><creationdate>20120514</creationdate><title>n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet</title><author>Kasbi Chadli, Fatima ; Andre, Agnès ; Prieur, Xavier ; Loirand, Gervaise ; Meynier, Anne ; Krempf, Michel ; Nguyen, Patrick ; Ouguerram, Khadija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-488333686bc1de1f9df51e16aa8ae23cec557ceb127e104374f3ad6d3afc436e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipocytes - cytology</topic><topic>Adipose Tissue - metabolism</topic><topic>Animal Feed</topic><topic>Animals</topic><topic>Aorta - pathology</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body Weight</topic><topic>Carbohydrate Metabolism</topic><topic>CD36 Antigens - metabolism</topic><topic>Chemical and Process Engineering</topic><topic>Cholesterol</topic><topic>Cricetinae</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Dyslipidemias - metabolism</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Engineering Sciences</topic><topic>Fatty Acids, Omega-3 - metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Food engineering</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose - metabolism</topic><topic>Glucose Intolerance</topic><topic>Life Sciences</topic><topic>Lipid Metabolism</topic><topic>Lipids - blood</topic><topic>Lipoproteins, VLDL - metabolism</topic><topic>Liver - metabolism</topic><topic>Macrophages - cytology</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>Metabolic syndrome</topic><topic>Metabolism and Metabolic Studies</topic><topic>Muscles - metabolism</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Obesity - physiopathology</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasbi Chadli, Fatima</creatorcontrib><creatorcontrib>Andre, Agnès</creatorcontrib><creatorcontrib>Prieur, Xavier</creatorcontrib><creatorcontrib>Loirand, Gervaise</creatorcontrib><creatorcontrib>Meynier, Anne</creatorcontrib><creatorcontrib>Krempf, Michel</creatorcontrib><creatorcontrib>Nguyen, Patrick</creatorcontrib><creatorcontrib>Ouguerram, Khadija</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasbi Chadli, Fatima</au><au>Andre, Agnès</au><au>Prieur, Xavier</au><au>Loirand, Gervaise</au><au>Meynier, Anne</au><au>Krempf, Michel</au><au>Nguyen, Patrick</au><au>Ouguerram, Khadija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2012-05-14</date><risdate>2012</risdate><volume>107</volume><issue>9</issue><spage>1305</spage><epage>1315</epage><pages>1305-1315</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract><![CDATA[Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were studied for 20 weeks: (1) control diet (Control); (2) high-fat diet (HF); (3) high-fat diet enriched with n-3 PUFA (HFn-3) groups. The increase in body weight and fat mass in the HF compared to the Control group (P < 0·05) was not found in the HFn-3 group. Muscle TAG content was similar in the Control and HF groups, but significantly lower in the HFn-3 group (P = 0·008). Glucose tolerance was impaired in the HF compared to the Control group, but this impairment was prevented by n-3 PUFA in the HFn-3 group (P < 0·001). Plasma TAG and cholesterol were higher in the HF group compared to the Control group (P < 0·001), but lower in the HFn-3 group compared to the HF group (P < 0·001). HDL-cholesterol was lower in the HFn-3 group compared to the Control and HF groups (P < 0·0005). Hepatic secretion of TAG was lower in the HFn-3 group compared to the HF group (P < 0·005), but did not differ from the Control group. Hepatic gene expression of sterol regulatory element-binding protein-1c, diacylglycerol O-acyltransferase 2 and stearyl CoA desaturase 1 was lower in the HFn-3 group, whereas carnitine palmitoyl transferase 1 and scavenger receptor class B type 1 expression was higher (P < 0·05). In adipocytes and adipose macrophages, PPARγ and TNFα expression was higher in the HF and HFn-3 groups compared to the Control group. Endothelium relaxation was higher in the HFn-3 (P < 0·001) than in the HF and Control groups, and was correlated with glucose intolerance (P = 0·03) and cholesterol (P = 0·0003). In conclusion, n-3 PUFA prevent some metabolic disturbances induced by high-fat diet and improve endothelial function in hamsters.]]></abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>21920060</pmid><doi>10.1017/S0007114511004387</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2306-3931</orcidid><orcidid>https://orcid.org/0000-0002-7629-3482</orcidid><orcidid>https://orcid.org/0000-0003-0058-6462</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2012-05, Vol.107 (9), p.1305-1315 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02644896v1 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals; Free Full-Text Journals in Chemistry |
| subjects | Adipocytes - cytology Adipose Tissue - metabolism Animal Feed Animals Aorta - pathology Biological and medical sciences Body Composition Body Weight Carbohydrate Metabolism CD36 Antigens - metabolism Chemical and Process Engineering Cholesterol Cricetinae Diet Diet, High-Fat Dyslipidemias - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Engineering Sciences Fatty Acids, Omega-3 - metabolism Feeding. Feeding behavior Food engineering Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose Intolerance Life Sciences Lipid Metabolism Lipids - blood Lipoproteins, VLDL - metabolism Liver - metabolism Macrophages - cytology Male Mesocricetus Metabolic syndrome Metabolism and Metabolic Studies Muscles - metabolism Nutrition research Obesity Obesity - metabolism Obesity - physiopathology Risk factors Rodents Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T04%3A15%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=n-3%20PUFA%20prevent%20metabolic%20disturbances%20associated%20with%20obesity%20and%20improve%20endothelial%20function%20in%20golden%20Syrian%20hamsters%20fed%20with%20a%20high-fat%20diet&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Kasbi%20Chadli,%20Fatima&rft.date=2012-05-14&rft.volume=107&rft.issue=9&rft.spage=1305&rft.epage=1315&rft.pages=1305-1315&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114511004387&rft_dat=%3Cproquest_hal_p%3E1837343787%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1266711614&rft_id=info:pmid/21920060&rft_cupid=10_1017_S0007114511004387&rfr_iscdi=true |