n-3 PUFA prevent metabolic disturbances associated with obesity and improve endothelial function in golden Syrian hamsters fed with a high-fat diet

Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of nutrition 2012-05, Vol.107 (9), p.1305-1315
Hauptverfasser:	Kasbi Chadli, Fatima, Andre, Agnès, Prieur, Xavier, Loirand, Gervaise, Meynier, Anne, Krempf, Michel, Nguyen, Patrick, Ouguerram, Khadija
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipose Tissue - metabolism Animal Feed Animals Aorta - pathology Biological and medical sciences Body Composition Body Weight Carbohydrate Metabolism CD36 Antigens - metabolism Chemical and Process Engineering Cholesterol Cricetinae Diet Diet, High-Fat Dyslipidemias - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Engineering Sciences Fatty Acids, Omega-3 - metabolism Feeding. Feeding behavior Food engineering Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose Intolerance Life Sciences Lipid Metabolism Lipids - blood Lipoproteins, VLDL - metabolism Liver - metabolism Macrophages - cytology Male Mesocricetus Metabolic syndrome Metabolism and Metabolic Studies Muscles - metabolism Nutrition research Obesity Obesity - metabolism Obesity - physiopathology Risk factors Rodents Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were studied for 20 weeks: (1) control diet (Control); (2) high-fat diet (HF); (3) high-fat diet enriched with n-3 PUFA (HFn-3) groups. The increase in body weight and fat mass in the HF compared to the Control group (P
ISSN:	0007-1145 1475-2662
DOI:	10.1017/S0007114511004387