Subpopulations in aMPV vaccines are unlikely to be the only cause of reversion to virulence

Highlights • Development of different NGS protocols for aMPV full genome sequencing. • First study investigating aMPV vaccine subpopulation using NGS. • Comparison of identified SNV with attenuation/reversion to virulence markers. • Evidence of the role of intra-vaccine variability in vaccine revers...

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Veröffentlicht in:	Vaccine 2015-05, Vol.33 (21), p.2438-2441
Hauptverfasser:	Franzo, G, Naylor, C.J, Drigo, M, Croville, G, Ducatez, M.F, Catelli, E, Laconi, A, Cecchinato, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animal biology Animals Avian metapneumovirus Data analysis Deoxyribonucleic acid DNA Genetic Variation Genomes Haplotypes High-Throughput Nucleotide Sequencing Life Sciences Metapneumovirus - classification Metapneumovirus - genetics Metapneumovirus - isolation & purification Metapneumovirus - physiology Methods Microbiology and Parasitology Mutation NGS Protocol Reversion to virulence RNA, Viral - genetics Santé publique et épidémiologie Software Studies Subpopulations Vaccine Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - genetics Veterinary medicine and animal Health Viral subpopulation Viral Vaccines - administration & dosage Viral Vaccines - adverse effects Viral Vaccines - genetics Virology Virulence
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Zusammenfassung:	Highlights • Development of different NGS protocols for aMPV full genome sequencing. • First study investigating aMPV vaccine subpopulation using NGS. • Comparison of identified SNV with attenuation/reversion to virulence markers. • Evidence of the role of intra-vaccine variability in vaccine reversion to virulence.
ISSN:	0264-410X 1873-2518 0264-410X
DOI:	10.1016/j.vaccine.2015.03.092