Resolvin D1 and E1 promote resolution of inflammation in microglial cells in vitro

Highlights • Our work is the first to show that RvD1 and RvE1 are potent inhibitors of LPS-induced TNF-α, IL-6 and IL-1β gene expression. • RvD1 and RvE1 are modulators of microglial phenotype in vitro. • RvE1 regulates NFκB signaling pathway. • RvD1 regulates miRNAs expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-07, Vol.55, p.249-259
Hauptverfasser:	Rey, C, Nadjar, A, Buaud, B, Vaysse, C, Aubert, A, Pallet, V, Layé, S, Joffre, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals BV2 DHA Docosahexaenoic Acids - pharmacology Eicosapentaenoic Acid - analogs & derivatives Eicosapentaenoic Acid - pharmacology EPA Inflammation - drug therapy Interleukin-6 - metabolism Life Sciences Mice Microglia - drug effects Microglial cells MicroRNAs - metabolism miRNA n-3 PUFA Neuroinflammation Psychiatry RvD1 RvE1 Tumor Necrosis Factor-alpha - drug effects
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Beschreibung
Zusammenfassung:	Highlights • Our work is the first to show that RvD1 and RvE1 are potent inhibitors of LPS-induced TNF-α, IL-6 and IL-1β gene expression. • RvD1 and RvE1 are modulators of microglial phenotype in vitro. • RvE1 regulates NFκB signaling pathway. • RvD1 regulates miRNAs expression.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.12.013