Potent Anticancer Efficacy of First-In-Class Cu II and Au III Metaled Phosphorus Dendrons with Distinct Cell Death Pathways
First-in-class Cu and Au metaled phosphorus dendrons were synthesized and showed significant antiproliferative activity against several aggressive breast cancer cell lines. The data suggest that the cytotoxicity increases with reducing length of the alkyl chains, whereas the replacement of Cu with A...
Gespeichert in:
Veröffentlicht in: | Chemistry : a European journal 2020-05, Vol.26 (26), p.5903-5910 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | First-in-class Cu
and Au
metaled phosphorus dendrons were synthesized and showed significant antiproliferative activity against several aggressive breast cancer cell lines. The data suggest that the cytotoxicity increases with reducing length of the alkyl chains, whereas the replacement of Cu
with Au
considerably increases the antiproliferative activity of metaled phosphorus dendrons. Very interestingly, we found that the cell death pathway is related to the nature of the metal complexed by the plain dendrons. Cu
metaled dendrons showed a potent caspase-independent cell death pathway, whereas Au
metaled dendrons displayed a caspase-dependent apoptotic pathway. The complexation of plain dendrons with Au
increased the cellular lethality versus dendrons with Cu
and promoted the translocation of Bax into the mitochondria and the release of Cytochrome C (Cyto C). |
---|---|
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.202001014 |