Rhodium(III)-Catalyzed [4+3] Annulation of N -Aryl-pyrazolidinones and Propargylic Acetates: Access to Benzo[ c ][1,2]diazepines

Rhodium(III)-Catalyzed [4+3] Annulation of N -Aryl-pyrazolidinones and Propargylic Acetates: Access to Benzo[ c ][1,2]diazepines

The generation of 2,3-dihydro-benzo[ ][1,2]diazepine derivatives via rhodium(III)-catalyzed [4+3] annulation of pyrazolidinones and propargylic acetates is disclosed. The reaction proceeds smoothly under relatively mild conditions from propargylic acetates as novel C synthons. A range of dinitrogen-...

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Veröffentlicht in:Organic letters 2020-06, Vol.22 (11), p.4078-4082
Hauptverfasser: Li, Tingfang, Yang, Zi, Song, Zhenyu, Chauvin, Remi, Cui, Xiuling
Format: Artikel
Sprache:eng
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Chemical Sciences
Coordination chemistry
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Zusammenfassung:The generation of 2,3-dihydro-benzo[ ][1,2]diazepine derivatives via rhodium(III)-catalyzed [4+3] annulation of pyrazolidinones and propargylic acetates is disclosed. The reaction proceeds smoothly under relatively mild conditions from propargylic acetates as novel C synthons. A range of dinitrogen-fused heterocyclic compounds are readily accessed by this approach.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01139