Oncologic outcomes, prognostic factor analysis and therapeutic algorithm evaluation of head and neck mucosal melanomas in France

Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering t...

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Veröffentlicht in:	European journal of cancer (1990) 2019-12, Vol.123, p.1-10
Hauptverfasser:	Moya-Plana, A., Aupérin, A., Obongo, R., Baglin, A., Baujat, B., Saroul, N., Casiraghi, O., Vergez, S., Janot, F., Thariat, J., Vérillaud, B., de Gabory, L., Albert, S., Andry, G., Badet, J.-M., Badoual, C., Baglin, A.C., Barry, B., Bensadoun, R.J., Bertolus, C., Bessède, J.-P., Blanchard, D., Borel, C., Breheret, R., Breton, P., Brugel, L., Cassagnau, E., Castillo, L., Ceruse, P., Chabolle, F., Chevalier, D., Chobaut, J.C., Choussy, O., Cosmidis, A., Costes, V., Darrouzet, V., Demez, P., Dessi, P., Devauchelle, B., Digue, L., Dolivet, G., Dubrulle, F., Duflo, S., Faivre, S., Fakhry, N., Ferron, C., Floret, F., Garrel, R., Geoffrois, L., Giovanni, A., Girod, A., Guerrier, B., Hans, S., Herman, P., Hofman, P., Housset, M., Jankowski, R., Jegoux, F., Juliéron, M., Kaminsky, M.-C., Kolb, F., Lacau St Guily, J., Laccoureye, L., Lallemant, B., Lang, P., Lavieille, J.-P., Lefevre, M., Leroy, X., Malard, O., Mauvais, O., Merol, J.-C., Michel, J., Mom, T., Morinière, S., de Monès, E., Moulin, G., Noel, G., Poissonnet, G., Prades, J.-M., Reyt, E., Righini, C., Rolland, F., Sarroul, N., Schultz, P., Serrano, E., Sterkers, O., Strunski, V., Tassart, M., Testelin, S., Timochenko, A., Uro Coste, E., Valette, G., Van den Abbeele, T., Veillon, F., Wassef, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Cancer Factor analysis Head & neck cancer Head and neck Life Sciences Lymph nodes Medical prognosis Melanoma Metastases Metastasis Mucosa Mucosal melanoma Multivariate analysis Nodes Oral cavity Patients Prognosis Radiation therapy Radiotherapy Sinonasal Surgery Survival Tumors
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Zusammenfassung:	Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-metastasis (TNM) stage are not well established. Patients with HNMM from the prospective national French Rare Head and Neck Cancer Expert Network database between 2000 and 2017 were included. Clinical characteristics, treatment modalities, outcomes and prognostic factors were analysed. In total, 314 patients were included. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 49.4% and 24.7%, respectively, in the surgery group; no long-term survivors were observed when surgery was not feasible. Moreover, even after surgery, a high recurrence rate was reported with a median PFS of 22 months. In multivariate analysis, Union for International Cancer Control (UICC) stage and tumour site correlated with PFS and OS. Postoperative radiotherapy (PORT) improved the PFS but not OS in patients with small (T3) SNMM and OCMM tumours. Nodal involvement was more frequent in patients with OCMM (p
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2019.09.007