High expression of the RNA-binding protein RBPMS2 in gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are often associated with KIT or PDGFRA gene mutations. GIST cells might arise from the interstitial cells of Cajal (ICCs) or from a mesenchymal precursor that is common to ICCs and sm...

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Veröffentlicht in:	Experimental and molecular pathology 2013-04, Vol.94 (2), p.314-321
Hauptverfasser:	Hapkova, Ilona, Skarda, Josef, Rouleau, Caroline, Thys, An, Notarnicola, Cécile, Janikova, Maria, Bernex, Florence, Rypka, Miroslav, Vanderwinden, Jean-Marie, Faure, Sandrine, Vesely, Jaroslav, de Santa Barbara, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Sequence Cell Line, Tumor Female Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gastrointestinal stromal tumors (GIST) Gastrointestinal Stromal Tumors - genetics Gastrointestinal Stromal Tumors - metabolism Gastrointestinal Tract - metabolism Gene Expression HEK293 Cells Human health and pathology Humans Interstitial cell of Cajal Life Sciences Male Middle Aged Molecular Sequence Data Mutation Proto-Oncogene Proteins c-kit - antagonists & inhibitors Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism RBPMS2 Receptor, Platelet-Derived Growth Factor alpha - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - metabolism Signal Transduction Smooth muscle cells Tissues and Organs
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Zusammenfassung:	Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are often associated with KIT or PDGFRA gene mutations. GIST cells might arise from the interstitial cells of Cajal (ICCs) or from a mesenchymal precursor that is common to ICCs and smooth muscle cells (SMCs). Here, we analyzed the mRNA and protein expression of RNA-Binding Protein with Multiple Splicing-2 (RBPMS2), an early marker of gastrointestinal SMC precursors, in human GISTs (n=23) by in situ hybridization, quantitative RT-PCR analysis and immunohistochemistry. The mean RBPMS2 mRNA level in GISTs was 42-fold higher than in control gastrointestinal samples (p
ISSN:	0014-4800 1096-0945
DOI:	10.1016/j.yexmp.2012.12.004