Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids

Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids

Aging is accompanied by troubles resulting from changes in hormonal and nutritional status. Therefore, the abundance of mRNA coding for triiodothyronine (TR) and retinoic acid (RA) nuclear receptors was studied in the brain of young, adult and aged (2.5, 6 and 24 months, respectively) rats. In the b...

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Veröffentlicht in:FEBS letters 1997-08, Vol.412 (3), p.629-632
Hauptverfasser: Enderlin, V, Alfos, S, Pallet, V, Garcin, H, Azaı̈s-Braesco, V, Jaffard, R, Higueret, P
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Aging
Aging - drug effects
Aging - metabolism
Animals
Brain
Brain - drug effects
Brain - metabolism
Cognitive Sciences
Diterpenes
Intubation, Gastrointestinal
Life Sciences
Male
mRNA
Neurobiology
Neurons and Cognition
Nuclear receptor
Psychology and behavior
RAR
Rats
Rats, Wistar
Receptors, Retinoic Acid
Receptors, Retinoic Acid - drug effects
Receptors, Retinoic Acid - metabolism
Receptors, Retinoic Acid - physiology
Receptors, Thyroid Hormone
Receptors, Thyroid Hormone - drug effects
Receptors, Thyroid Hormone - metabolism
Receptors, Thyroid Hormone - physiology
Retinoid
RNA, Messenger
RNA, Messenger - drug effects
RNA, Messenger - metabolism
RNA, Messenger - physiology
Tretinoin
Tretinoin - administration & dosage
Vitamin A
Vitamin A - administration & dosage
Vitamin A - analogs & derivatives
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Zusammenfassung:Aging is accompanied by troubles resulting from changes in hormonal and nutritional status. Therefore, the abundance of mRNA coding for triiodothyronine (TR) and retinoic acid (RA) nuclear receptors was studied in the brain of young, adult and aged (2.5, 6 and 24 months, respectively) rats. In the brain of aged rats, there was a lower abundance of TR and RAR mRNA and a lower activity of tissue transglutaminase (tTG), an enzyme the gene of which is a target for retinoids. Administration of RA in these rats restored TR and RAR mRNA and the activity of tTG in the brain. The importance of these observations to the function of the aged brain is discussed.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(97)00845-4