Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the wa...

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Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2020-03, Vol.41 (3), p.142-146
Hauptverfasser: Dugé de Bernonville, Thomas, Papon, Nicolas, Clastre, Marc, O’Connor, Sarah E., Courdavault, Vincent
Format: Artikel
Sprache:eng
Schlagworte:
Biotechnology
coexpression network
gene identification
Life Sciences
RNA-seq
specialized metabolites
Vegetal Biology
whole genome sequencing
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Zusammenfassung:Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the way to engineered supplies of these compounds through synthetic biology approaches.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2019.12.006