Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study
Highlights • 27% oropharyngeal cancer patients (France) were HPV+; many were also smokers. • HPV+ patients had 2-fold better progression-free survival (PFS) than HPV-negative. • Only lack of upfront surgery had an equally strong effect on PFS as HPV. • Lack of upfront surgery was especially detrimen...
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| Veröffentlicht in: | Oral oncology 2017-04, Vol.67, p.29-36 |
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| container_title | Oral oncology |
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| creator | Lacau St Guily, Jean Rousseau, Alexandra Baujat, Bertrand Périé, Sophie Schultz, Philippe Barry, Béatrix Dufour, Xavier Malard, Olivier Pretet, Jean-Luc Clavel, Christine Birembaut, Philippe Franceschi, Silvia |
| description | Highlights • 27% oropharyngeal cancer patients (France) were HPV+; many were also smokers. • HPV+ patients had 2-fold better progression-free survival (PFS) than HPV-negative. • Only lack of upfront surgery had an equally strong effect on PFS as HPV. • Lack of upfront surgery was especially detrimental in HPV-negative patients. • Poorer PFS in HPV-negative may derive from more genomic damage or bulkier tumours. |
| doi_str_mv | 10.1016/j.oraloncology.2017.01.012 |
| format | Article |
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All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-689d5c96dbd6ddfb9d5ffff92734b64c394391e32e8d8f4cf0c12046b931073b3</citedby><cites>FETCH-LOGICAL-c469t-689d5c96dbd6ddfb9d5ffff92734b64c394391e32e8d8f4cf0c12046b931073b3</cites><orcidid>0000-0002-8430-214X ; 0000-0003-4181-8071</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1368837517300209$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28351578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-reims.fr/hal-02451668$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lacau St Guily, Jean</creatorcontrib><creatorcontrib>Rousseau, Alexandra</creatorcontrib><creatorcontrib>Baujat, Bertrand</creatorcontrib><creatorcontrib>Périé, Sophie</creatorcontrib><creatorcontrib>Schultz, Philippe</creatorcontrib><creatorcontrib>Barry, Béatrix</creatorcontrib><creatorcontrib>Dufour, Xavier</creatorcontrib><creatorcontrib>Malard, Olivier</creatorcontrib><creatorcontrib>Pretet, Jean-Luc</creatorcontrib><creatorcontrib>Clavel, Christine</creatorcontrib><creatorcontrib>Birembaut, Philippe</creatorcontrib><creatorcontrib>Franceschi, Silvia</creatorcontrib><creatorcontrib>The Papillophar Group</creatorcontrib><creatorcontrib>Papillophar Group</creatorcontrib><title>Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>Highlights • 27% oropharyngeal cancer patients (France) were HPV+; many were also smokers. • HPV+ patients had 2-fold better progression-free survival (PFS) than HPV-negative. • Only lack of upfront surgery had an equally strong effect on PFS as HPV. • Lack of upfront surgery was especially detrimental in HPV-negative patients. • Poorer PFS in HPV-negative may derive from more genomic damage or bulkier tumours.</description><subject>Alphapapillomavirus - isolation & purification</subject><subject>Female</subject><subject>France</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Oropharyngeal cancer</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>Otolaryngology</subject><subject>Prognosis</subject><subject>Progression-free survival</subject><subject>Surgical treatment</subject><subject>Survival</subject><subject>Tobacco</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQjRCIfsBfQBYnOGQZ24lj94BUlZZFWqmVKFwtx3Z2vTjxYieV8u9x2FIhTlgjeWy9eaN5b4riLYYVBsw-7FchKh8GHXzYzisCuFkBzkGeFaeYN6KEWtDnOaeMl5w29UlxltIeAGpcw8vihHCas4afFuo2hsNOxXnYWuWRVoO2ER1i2A4huYTaGY1TH6aI1nffURrVOCXkBnQTF-QFut9Z1E9-dNoOY3Qa3amD8_43Z4ZPZn5VvOiUT_b1431efLu5vr9al5vbz1-uLjelrpgYS8aFqbVgpjXMmK7Nry4fQRpatazSVFRUYEuJ5YZ3le5AYwIVawXF0NCWnhfvj7w75eUhuj4PJYNycn25kcsfkKrGjPEHnLHvjtg86M_JplH2LmnrvRpsmJLEnBPgWWyeoRdHqI4hpWi7J24McrFD7uXfdsjFDgk4B8nFbx77TG1vzVPpH_0z4NMRYLMyD85GmbSzWVnjotWjNMH9X5-P_9Bo7wanlf9hZ5v22b8hay-xTESC_LosxrIXuKEABAT9Bd4DuFc</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Lacau St Guily, Jean</creator><creator>Rousseau, Alexandra</creator><creator>Baujat, Bertrand</creator><creator>Périé, Sophie</creator><creator>Schultz, Philippe</creator><creator>Barry, Béatrix</creator><creator>Dufour, Xavier</creator><creator>Malard, Olivier</creator><creator>Pretet, Jean-Luc</creator><creator>Clavel, Christine</creator><creator>Birembaut, Philippe</creator><creator>Franceschi, Silvia</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-8430-214X</orcidid><orcidid>https://orcid.org/0000-0003-4181-8071</orcidid></search><sort><creationdate>20170401</creationdate><title>Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study</title><author>Lacau St Guily, Jean ; Rousseau, Alexandra ; Baujat, Bertrand ; Périé, Sophie ; Schultz, Philippe ; Barry, Béatrix ; Dufour, Xavier ; Malard, Olivier ; Pretet, Jean-Luc ; Clavel, Christine ; Birembaut, Philippe ; Franceschi, Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-689d5c96dbd6ddfb9d5ffff92734b64c394391e32e8d8f4cf0c12046b931073b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alphapapillomavirus - isolation & purification</topic><topic>Female</topic><topic>France</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Oropharyngeal cancer</topic><topic>Oropharyngeal Neoplasms - virology</topic><topic>Otolaryngology</topic><topic>Prognosis</topic><topic>Progression-free survival</topic><topic>Surgical treatment</topic><topic>Survival</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lacau St Guily, Jean</creatorcontrib><creatorcontrib>Rousseau, Alexandra</creatorcontrib><creatorcontrib>Baujat, Bertrand</creatorcontrib><creatorcontrib>Périé, Sophie</creatorcontrib><creatorcontrib>Schultz, Philippe</creatorcontrib><creatorcontrib>Barry, Béatrix</creatorcontrib><creatorcontrib>Dufour, Xavier</creatorcontrib><creatorcontrib>Malard, Olivier</creatorcontrib><creatorcontrib>Pretet, Jean-Luc</creatorcontrib><creatorcontrib>Clavel, Christine</creatorcontrib><creatorcontrib>Birembaut, Philippe</creatorcontrib><creatorcontrib>Franceschi, Silvia</creatorcontrib><creatorcontrib>The Papillophar Group</creatorcontrib><creatorcontrib>Papillophar Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lacau St Guily, Jean</au><au>Rousseau, Alexandra</au><au>Baujat, Bertrand</au><au>Périé, Sophie</au><au>Schultz, Philippe</au><au>Barry, Béatrix</au><au>Dufour, Xavier</au><au>Malard, Olivier</au><au>Pretet, Jean-Luc</au><au>Clavel, Christine</au><au>Birembaut, Philippe</au><au>Franceschi, Silvia</au><aucorp>The Papillophar Group</aucorp><aucorp>Papillophar Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>67</volume><spage>29</spage><epage>36</epage><pages>29-36</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>Highlights • 27% oropharyngeal cancer patients (France) were HPV+; 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alphapapillomavirus - isolation & purification Female France Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Life Sciences Male Oropharyngeal cancer Oropharyngeal Neoplasms - virology Otolaryngology Prognosis Progression-free survival Surgical treatment Survival Tobacco |
| title | Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study |
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