Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study

Highlights • 27% oropharyngeal cancer patients (France) were HPV+; many were also smokers. • HPV+ patients had 2-fold better progression-free survival (PFS) than HPV-negative. • Only lack of upfront surgery had an equally strong effect on PFS as HPV. • Lack of upfront surgery was especially detrimen...

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Veröffentlicht in:	Oral oncology 2017-04, Vol.67, p.29-36
Hauptverfasser:	Lacau St Guily, Jean, Rousseau, Alexandra, Baujat, Bertrand, Périé, Sophie, Schultz, Philippe, Barry, Béatrix, Dufour, Xavier, Malard, Olivier, Pretet, Jean-Luc, Clavel, Christine, Birembaut, Philippe, Franceschi, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphapapillomavirus - isolation & purification Female France Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Life Sciences Male Oropharyngeal cancer Oropharyngeal Neoplasms - virology Otolaryngology Prognosis Progression-free survival Surgical treatment Survival Tobacco
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Zusammenfassung:	Highlights • 27% oropharyngeal cancer patients (France) were HPV+; many were also smokers. • HPV+ patients had 2-fold better progression-free survival (PFS) than HPV-negative. • Only lack of upfront surgery had an equally strong effect on PFS as HPV. • Lack of upfront surgery was especially detrimental in HPV-negative patients. • Poorer PFS in HPV-negative may derive from more genomic damage or bulkier tumours.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2017.01.012