Tandem zinc mediated reductive cleavage-reductive amination as a new approach to substituted pyrrolidines from homoallylic amines

N-Boc or N-Cbz homoallylic amines are converted in four steps into pyrrolidines through a sequence involving as a key-step a tandem zinc mediated reductive cleavage-reductive amination from an intermediate 1,3-oxazin-2-one N-Cbz or N-Boc homoallylic amines are converted in four steps into substitute...

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Veröffentlicht in:Tetrahedron letters 1995-04, Vol.36 (17), p.2971-2974
Hauptverfasser: Vanucci, Corinne, Brusson, Xavier, Verdel, Valérie, Zana, Frédérique, Dhimane, Hamid, Lhommet, Gérard
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Sprache:eng
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Zusammenfassung:N-Boc or N-Cbz homoallylic amines are converted in four steps into pyrrolidines through a sequence involving as a key-step a tandem zinc mediated reductive cleavage-reductive amination from an intermediate 1,3-oxazin-2-one N-Cbz or N-Boc homoallylic amines are converted in four steps into substituted pyrrolidines via an intermediate oxazinone.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)00354-F