Tandem zinc mediated reductive cleavage-reductive amination as a new approach to substituted pyrrolidines from homoallylic amines
N-Boc or N-Cbz homoallylic amines are converted in four steps into pyrrolidines through a sequence involving as a key-step a tandem zinc mediated reductive cleavage-reductive amination from an intermediate 1,3-oxazin-2-one N-Cbz or N-Boc homoallylic amines are converted in four steps into substitute...
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Veröffentlicht in: | Tetrahedron letters 1995-04, Vol.36 (17), p.2971-2974 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | N-Boc or N-Cbz homoallylic amines are converted in four steps into pyrrolidines through a sequence involving as a key-step a tandem zinc mediated reductive cleavage-reductive amination from an intermediate 1,3-oxazin-2-one
N-Cbz or N-Boc homoallylic amines are converted in four steps into substituted pyrrolidines via an intermediate oxazinone. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/0040-4039(95)00354-F |