Sequential radical cyclization of β-functionalized allyl bromomethyldimethylsilyl ethers. Application to the regio- and stereo-specific synthesis of an isoprostanoid precursor

The behaviour of allyl bromomethyldimethylsilyl ethers β-substituted by various radical trapping functions (aldehyde, nitrile or acetylenic) is studied in tandem radical cyclizations. Only homopropargylic ethers (but-3-ynylic ethers) lead to the formation of cyclic compounds via a 5-exo-trig, 5-exo-...

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Veröffentlicht in:Journal of the Chemical Society, Perkin Transactions 1 Perkin Transactions 1, 1999 (6), p.697-704
Hauptverfasser: Belval, Florence, Fruchier, Alain, Chavis, Claude, Montero, Jean-Louis, Lucas, Marc
Format: Artikel
Sprache:eng
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Zusammenfassung:The behaviour of allyl bromomethyldimethylsilyl ethers β-substituted by various radical trapping functions (aldehyde, nitrile or acetylenic) is studied in tandem radical cyclizations. Only homopropargylic ethers (but-3-ynylic ethers) lead to the formation of cyclic compounds via a 5-exo-trig, 5-exo-dig or 5-exo-trig, 6-endo-dig mode. The influence of the TMS group located on the acetylenic moiety is shown to be determinant for the regio- and stereo-specific C5 ring closure (5-exo-dig mode).
ISSN:0300-922X
1472-7781
1364-5463
DOI:10.1039/a809281h