Reversing pancreatic cancer immunosuppression through pharmacological targeting of activated pancreatic stellate cells

Reversing pancreatic cancer immunosuppression through pharmacological targeting of activated pancreatic stellate cells

Stromal activated Pancreatic Stellate Cells (PSC) secrete soluble and extracellular matrix (ECM) proteins that promote cancer cell aggressiveness and immunosuppression. Longitudinal monitoring of tumor volumes by ultrasound, as well as histopathology and flow cytometry analyses, are performed on pan...

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Veröffentlicht in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-07, Vol.17 (3), p.S44-S45
Hauptverfasser: Bousquet, Corinne, Samain, Rémi, Rochotte, Julia, Cassant-Sourdy, Stéphanie, Schmid, Herbert, Perraud, Aurélie, Mathonnet, Muriel, Martineau, Yvan, Pyronnet, Stéphane, Jean, Christine
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Endocrinology & Metabolism
Gastroenterology and Hepatology
Immunosuppression
Life Sciences
Pancreatic cancer
Protein synthesis
Proteins
Rodents
Stellate cells
Tumors
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Zusammenfassung:Stromal activated Pancreatic Stellate Cells (PSC) secrete soluble and extracellular matrix (ECM) proteins that promote cancer cell aggressiveness and immunosuppression. Longitudinal monitoring of tumor volumes by ultrasound, as well as histopathology and flow cytometry analyses, are performed on pancreatic tumors isolated from transgenic KPC mice (Pdx-1-Cre ; LSL-KrasG12D/+; LSL-Trp53R172H/+), or...
ISSN:1424-3903
1424-3909
1424-3911
DOI:10.1016/j.pan.2017.05.139