A case of Whipple's disease mimicking auto-inflammatory disease and revealed by severe right cardiac failure under anakinra

A case of Whipple's disease mimicking auto-inflammatory disease and revealed by severe right cardiac failure under anakinra

•A Whipple's disease can mimic Still's disease.•A Whipple's disease can be unmasked by an anti-IL-1RA.•Whipple's disease can lead to pulmonary hypertension and severe heart failure.•High blood pressure and right heart failure are totally regressive under well-managed antibiotic t...

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Veröffentlicht in:Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2020-07, Vol.87 (4), p.365-366
Hauptverfasser: Brevet, Pauline, Rottenberg, Pascal, Viacroze, Catherine, Schleifer, Dominique, Lequerre, Thierry, Vittecoq, Olivier
Format: Artikel
Sprache:eng
Schlagworte:
Anakinra
Anti-IL-1RA
Life Sciences
Pulmonary hypertension
Right cardiac failure
Whipple disease
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Zusammenfassung:•A Whipple's disease can mimic Still's disease.•A Whipple's disease can be unmasked by an anti-IL-1RA.•Whipple's disease can lead to pulmonary hypertension and severe heart failure.•High blood pressure and right heart failure are totally regressive under well-managed antibiotic treatment.•PCR Whipple on urine is not sensitive and should not be used (negative PCR while the patient had a disseminated disease).
ISSN:1297-319X
1778-7254
DOI:10.1016/j.jbspin.2019.11.004