Metal Ions in Alzheimer’s Disease: A Key Role or Not?

Metal Ions in Alzheimer’s Disease: A Key Role or Not?

Conspectus Despite tremendous research efforts in universities and pharmaceutical companies, effective drugs are still lacking for the treatment of Alzheimer’s disease (AD). The biochemical mechanisms of this devastating neurodegenerative disease have not yet been clearly understood. Besides a small...

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Veröffentlicht in:Accounts of chemical research 2019-07, Vol.52 (7), p.2026-2035
Hauptverfasser: Liu, Yan, Nguyen, Michel, Robert, Anne, Meunier, Bernard
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biochemistry, Molecular Biology
Chemical Sciences
Coordination chemistry
Life Sciences
Neurobiology
Neurons and Cognition
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Zusammenfassung:Conspectus Despite tremendous research efforts in universities and pharmaceutical companies, effective drugs are still lacking for the treatment of Alzheimer’s disease (AD). The biochemical mechanisms of this devastating neurodegenerative disease have not yet been clearly understood. Besides a small percentage of cases with early onset disease having a genetic origin (
ISSN:0001-4842
1520-4898
DOI:10.1021/acs.accounts.9b00248