Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane
The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
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| Veröffentlicht in: | Organic & biomolecular chemistry 2003-08, Vol.1 (16), p.2859 |
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| container_issue | 16 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Berrien, Jean-François Provot, Olivier Mayrargue, Joëlle Coquillay, Michel Cicéron, Liliane Gay, Frédérick Danis, Martin Robert, Anne Meunier, Bernard |
| description | The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented. |
| doi_str_mv | 10.1039/b302835f |
| format | Article |
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| ispartof | Organic & biomolecular chemistry, 2003-08, Vol.1 (16), p.2859 |
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| language | eng |
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| source | MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alkylation Animals Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Chemical Sciences Chloroquine - pharmacology Crystallography, X-Ray Heme - chemistry Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Inhibitory Concentration 50 Medicinal Chemistry Metalloporphyrins - chemistry Models, Chemical Molecular Structure Organic chemistry Plasmodium falciparum - drug effects Plasmodium falciparum - genetics |
| title | Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane |
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