Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane

The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2003-08, Vol.1 (16), p.2859
Hauptverfasser:	Berrien, Jean-François, Provot, Olivier, Mayrargue, Joëlle, Coquillay, Michel, Cicéron, Liliane, Gay, Frédérick, Danis, Martin, Robert, Anne, Meunier, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Chemical Sciences Chloroquine - pharmacology Crystallography, X-Ray Heme - chemistry Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry Heterocyclic Compounds - pharmacology Inhibitory Concentration 50 Medicinal Chemistry Metalloporphyrins - chemistry Models, Chemical Molecular Structure Organic chemistry Plasmodium falciparum - drug effects Plasmodium falciparum - genetics
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Beschreibung
Zusammenfassung:	The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b302835f