A Convenient Metal-Free Synthesis of (E)-3-Styrylisocoumarins through Annulation of (E)-1,4-Diarylenynes

A Convenient Metal-Free Synthesis of (E)-3-Styrylisocoumarins through Annulation of (E)-1,4-Diarylenynes

Abstract A metal-free procedure for the cyclization of ( E )-1,4-di­arylenynes is described. The reaction is promoted by a catalytic amount of p -toluenesulfonic acid and takes place in ethanol at 160 °C under microwave irradiation to afford stereoselectively ( E )-3-styrylisocoumarins in good to ex...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Synthesis (Stuttgart) 2016-10, Vol.48 (19), p.3382-3392
Hauptverfasser: Zhao, Guangkuan, Yuan, Ling-Zhi, Roudier, Mylène, Peyrat, Jean-François, Hamze, Abdallah, Brion, Jean-Daniel, Provot, Olivier, Alami, Mouad
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemical Sciences
Organic chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract A metal-free procedure for the cyclization of ( E )-1,4-di­arylenynes is described. The reaction is promoted by a catalytic amount of p -toluenesulfonic acid and takes place in ethanol at 160 °C under microwave irradiation to afford stereoselectively ( E )-3-styrylisocoumarins in good to excellent yields.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0035-1562501