Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard α-tocopherol. The synthesis and in vitro neuroprotective activity of the title com...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-10, Vol.9 (20), p.2929-2934
Hauptverfasser:	Larget, Ronan, Lockhart, Brian, Pfeiffer, Bruno, Neudorffer, Anne, Fleury, Maurice-Bernard, Largeron, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminophenols - chemical synthesis Aminophenols - pharmacology Animals Antioxidants Antioxidants - chemical synthesis Antioxidants - pharmacology Biological and medical sciences Cell Line Cellular Biology Chemical Sciences Hippocampus - drug effects Life Sciences Medical sciences Mice Neuropharmacology Neuroprotective agent Neuroprotective agents Neuroprotective Agents - chemical synthesis Neuroprotective Agents - pharmacology Organic chemistry Pharmacology. Drug treatments Radical scavengers Substituent effects Vitamin E - pharmacology
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Zusammenfassung:	A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard α-tocopherol. The synthesis and in vitro neuroprotective activity of the title compounds are described. [Display omitted]
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00504-1