Synthesis of tetrasubstituted α-fluoroenones

We reported the synthesis of tetrasubstituted α-fluoroenones from tetrasubstituted gem-bromofluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecule...

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Veröffentlicht in:Tetrahedron 2009-08, Vol.65 (31), p.6034-6038
Hauptverfasser: Dutheuil, Guillaume, Couve-Bonnaire, Samuel, Pannecoucke, Xavier
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container_end_page 6038
container_issue 31
container_start_page 6034
container_title Tetrahedron
container_volume 65
creator Dutheuil, Guillaume
Couve-Bonnaire, Samuel
Pannecoucke, Xavier
description We reported the synthesis of tetrasubstituted α-fluoroenones from tetrasubstituted gem-bromofluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecules and could also be envisioned to design new constrained peptidomimetics. [Display omitted]
doi_str_mv 10.1016/j.tet.2009.05.065
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subjects Aliphatic compounds
Biochemistry, Molecular Biology
Cancer
Catalysis
Chemical Sciences
Chemistry
Coordination chemistry
Exact sciences and technology
Inorganic chemistry
Life Sciences
or physical chemistry
Organic chemistry
Preparations and properties
Theoretical and
title Synthesis of tetrasubstituted α-fluoroenones
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