Synthesis of tetrasubstituted α-fluoroenones

We reported the synthesis of tetrasubstituted α-fluoroenones from tetrasubstituted gem-bromofluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecule...

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Veröffentlicht in:	Tetrahedron 2009-08, Vol.65 (31), p.6034-6038
Hauptverfasser:	Dutheuil, Guillaume, Couve-Bonnaire, Samuel, Pannecoucke, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Biochemistry, Molecular Biology Cancer Catalysis Chemical Sciences Chemistry Coordination chemistry Exact sciences and technology Inorganic chemistry Life Sciences or physical chemistry Organic chemistry Preparations and properties Theoretical and
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Zusammenfassung:	We reported the synthesis of tetrasubstituted α-fluoroenones from tetrasubstituted gem-bromofluoroolefins in good yields. These compounds are scarcely studied in the literature, due to difficulty of synthesis, whereas they could serve as intermediates in the synthesis of biological relevant molecules and could also be envisioned to design new constrained peptidomimetics. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2009.05.065