New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support

We proposed an improved methodology for soluble PEG-supported synthesis of 5′-nucleotide derivatives from cytidine using a carboxylethoxy linker. Compared to our previous work, no by-product is formed during cleavage from the support and dialysis is not required anymore for purification.

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Bibliographische Detailangaben
Veröffentlicht in:	New journal of chemistry 2018-10, Vol.42 (20), p.16441-16445
Hauptverfasser:	Depaix, Anaïs, Puy, Jean-Yves, Roy, Béatrice, Peyrottes, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology Chemical Sciences Dialysis Life Sciences Medicinal Chemistry Nucleotides Organic chemistry Polyethylene glycol
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	We proposed an improved methodology for soluble PEG-supported synthesis of 5′-nucleotide derivatives from cytidine using a carboxylethoxy linker. Compared to our previous work, no by-product is formed during cleavage from the support and dialysis is not required anymore for purification.
ISSN:	1144-0546 1369-9261
DOI:	10.1039/C8NJ03753A